Trial · NCT07896226
A Single Dose of Intravenous Penicillin as an Adjunct to Oral Penicillin in the Treatment of Acute Tonsillitis, Peritonsillar Phlegmon, and Peritonsillar Abscess
NCT07896226, Phase 4, Recruiting, Tejs Ehlers Klug
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Single Dose of Intravenous Penicillin as an Adjunct to Oral Penicillin in the Treatment of Acute Tonsillitis, Peritonsillar Phlegmon, and Peritonsillar Abscess. Trials, record NCT07896226. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07896226
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Single Dose of Intravenous Penicillin as an Adjunct to Oral Penicillin in the Treatment of Acute Tonsillitis, Peritonsillar Phlegmon, and Peritonsillar Abscess
- NCT number
- NCT07896226
- Status
- Recruiting
- Phases
- Phase 4
- Enrollment
- 154 participants, estimated
- Lead sponsor
- Tejs Ehlers Klug
- Conditions
- Acute Tonsillitis, Peritonsillar Abscess, Peritonsillar Cellulitis
- Interventions
- Benzylpenicillin, Isotonic NaCl (Placebo)
- First posted
- 2026-10-26
- Last updated
- 2026-11-04
Source ClinicalTrials.gov
Registered outcomes13
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | STAT-10 Score | Day 2 (the day after enrollment) | Sore Throat Assessment Tool-10 (STAT-10), a disease-specific patient-reported outcome measure. Ten items, each rated from 1 (not at all) to 5 (to a very high degree); total score range 10-50, with higher scores indicating greater symptom burden. Assessed in the acute tonsillitis (AT) and peritonsillar phlegmon (PP) groups. |
| Primary | PTAAT-12 Score | Day 2 (the day after enrollment) | Peritonsillar Abscess Assessment Tool-12 (PTAAT-12), a disease-specific patient-reported outcome measure. Twelve items, each rated from 1 (not at all) to 5 (to a very high degree); total score range 12-60, with higher scores indicating greater symptom burden. Assessed in the peritonsillar abscess (PTA) group. |
| Primary | Time to Symptom Resolution | From enrollment until reported recovery (daily questionnaire, days 1-7) | Time from enrollment to the first day on which the participant reports feeling recovered in the daily electronic questionnaire. All patients (AT, PP, and PTA groups). |
| Secondary | VAS Pain Score | Day 2 (the day after enrollment) | Throat pain measured on a Visual Analogue Scale (VAS) from 0 (no pain) to 10 (worst imaginable pain); higher scores indicate more pain (worse outcome). Reported as: (a) average pain during the day, (b) maximum pain during the day, (c) minimum pain during the day, and (d) current pain. All patients (AT, PP, and PTA groups). |
| Secondary | Use of Analgesics | Days 1-7 (collectively) | Total consumption of the standardized as-needed analgesics (paracetamol and ibuprofen) during days 1-7. All patients (AT, PP, and PTA groups). |
| Secondary | Accumulated PTAAT-12 Score | Days 1-7 (collectively) | Sum of daily PTAAT-12 scores during days 1-7 (each daily score 12-60; higher scores indicate greater symptom burden). Peritonsillar abscess (PTA) group. |
| Secondary | Accumulated STAT-10 Score | Days 1-7 (collectively) | Sum of daily STAT-10 scores during days 1-7 (each daily score 10-50; higher scores indicate greater symptom burden). Acute tonsillitis (AT) and peritonsillar phlegmon (PP) groups. |
| Secondary | Complications | From enrollment to 14 days follow-up | Occurrence of complications within 14 days of inclusion. AT and PP groups: hospital admission, abscess formation, and spread of infection. PTA group: hospital admission, tonsillectomy, and spread of infection. |
| Secondary | TOI-14 Score | At 6 and 12 months follow-up, respectively | Tonsillectomy Outcome Inventory-14 (TOI-14), a patient-reported questionnaire on throat-related symptoms and their consequences during the preceding 6 months. Fourteen items, each rated on a 6-point scale from 'no problem' to 'problem as bad as it can be'; higher scores indicate greater burden. All patients (AT, PP, and PTA groups). |
| Secondary | Tonsillectomy | From enrollment to 12 months follow-up | Proportion of patients who have undergone tonsillectomy. All patients (AT, PP, and PTA groups). |
1 to 10 of 13Source ClinicalTrials.gov
See all 13 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers14
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07896226
GET https://conductscience.org/api/trials/v1/NCT07896226/registered