Trial · NCT07897500
Dapagliflozin in Patients With Non-Obstructive Hypertrophic Cardiomyopathy: A Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
NCT07897500, Phase 4, Not yet recruiting, Yonsei University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Dapagliflozin in Patients With Non-Obstructive Hypertrophic Cardiomyopathy: A Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. Trials, record NCT07897500. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07897500
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Dapagliflozin in Patients With Non-Obstructive Hypertrophic Cardiomyopathy: A Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
- NCT number
- NCT07897500
- Status
- Not yet recruiting
- Phases
- Phase 4
- Enrollment
- 440 participants, estimated
- Lead sponsor
- Yonsei University
- Conditions
- Nonobstructive Hypertrophic Cardiomyopathy
- Interventions
- Dapagliflozin 10mg, Dapagliflozin Placebo
- First posted
- 2026-10-27
- Last updated
- 2026-10-27
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change From Baseline in Peak Oxygen Consumption (Peak VO₂) at Week 24 | Baseline and Week 24 | Exercise capacity will be assessed by cardiopulmonary exercise testing (CPET). The primary endpoint is the change from baseline to Week 24 in peak oxygen consumption (peak VO₂, mL/kg/min). |
| Secondary | Change From Baseline in Cardiopulmonary Exercise Testing Parameters at Week 24 | Baseline and Week 24 | Change From Baseline in Cardiopulmonary Exercise Testing Parameters at Week 24 * Proportion of Participants Achieving an Improvement of at Least 1.5 mL/kg/min in Peak VO₂ (%) at Week 24 * Change From Baseline in Metabolic Equivalents (METs) at Week 24 * Change From Baseline in Exercise Duration (min) at Week 24 * Change From Baseline in Ventilatory Efficiency (VE/VCO₂ Ratio) at Week 24 * Change From Baseline in Ventilatory Anaerobic Threshold (VAT, mL/kg/min) at Week 24 |
| Secondary | Change From Baseline in Echocardiographic Parameters at Week 24 | Baseline and Week 24 | Change From Baseline in Echocardiographic Parameters at Week 24 * Change From Baseline in Left Ventricular Global Longitudinal Strain (%) at Week 24 * Change From Baseline in Left Atrial Reservoir Strain (%) at Week 24 * Change From Baseline in Septal e' Velocity (cm/s) at Week 24 * Change From Baseline in E/e' Ratio at Week 24 * Change From Baseline in Pulmonary Artery Systolic Pressure (PASP, mmHg) at Week 24 * Change From Baseline in Left Ventricular Mass Index by Echocardiography (g/m²) at Week 24 * Change From Baseline in Left Ventricular End-Diastolic Dimension (mm) at Week 24 * Change From Baseline in Left Atrial Dimension (mm) at Week 24 |
| Secondary | Change From Baseline in Blood Biomarkers at Week 24 | Baseline and Week 24 | Change From Baseline in Blood Biomarkers at Week 24 * Change From Baseline in N-terminal Pro-B-type Natriuretic Peptide (NT-proBNP, pg/mL) at Week 24 * Change From Baseline in Troponin T (pg/mL) at Week 24 |
| Secondary | Change From Baseline in Symptoms and Health Status at Week 24 | Baseline and Week 24 | Change From Baseline in Symptoms at Week 24 * Change From Baseline in New York Heart Association (NYHA) Functional Class (Class I-IV) at Week 24 * Change From Baseline in Kansas City Cardiomyopathy Questionnaire (KCCQ) Overall Summary Score (points) at Week 24 |
| Secondary | Change From Baseline in Arrhythmic Burden on 24-Hour Ambulatory Electrocardiography at Week 24 | Baseline and Week 24 | Change From Baseline in Arrhythmic Burden Assessed by 24-Hour Ambulatory Electrocardiography at Week 24 * Change From Baseline in APC Burden (%) at Week 24 * Change From Baseline in VPC Burden (%) at Week 24 |
| Secondary | Change From Baseline in Cardiac Magnetic Resonance Imaging Parameters at Week 24 | Baseline and Week 24 | Change From Baseline in Cardiac Magnetic Resonance Imaging Parameters at Week 24(Severance Hospital substudy only) |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07897500
GET https://conductscience.org/api/trials/v1/NCT07897500/registered