Trial · NCT07898865
NeoCSR-Omics Trial: CAPOX + Serplulimab Before vs. After Short-course RT in LARC
NCT07898865, Phase 2, Recruiting, Chongqing University Cancer Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. NeoCSR-Omics Trial: CAPOX + Serplulimab Before vs. After Short-course RT in LARC. Trials, record NCT07898865. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07898865
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- NeoCSR-Omics Trial: CAPOX + Serplulimab Before vs. After Short-course RT in LARC
- NCT number
- NCT07898865
- Status
- Recruiting
- Phases
- Phase 2
- Enrollment
- 100 participants, estimated
- Lead sponsor
- Chongqing University Cancer Hospital
- Conditions
- Rectal Cancer Patients, Locally Advanced Rectal Cancer (LARC)
- Interventions
- radiotherapy, CAPOX (oxaliplatin/capecitabine), Serplulimab
- First posted
- 2026-10-27
- Last updated
- 2026-10-27
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Complete Response (CR) | one year | CR is defined as the proportion of patients achieving either pathological complete response (pCR, no residual viable tumor in the resected specimen) after radical surgery or clinical complete response (cCR, absence of residual tumor confirmed by endoscopy, digital rectal examination, and pelvic MRI in patients managed with organ preservation). |
| Secondary | Treatment-related adverse events | three months | |
| Secondary | Incidence of surgical complications | 30 days | |
| Secondary | Changes in immune microenvironment | Baseline, after neoadjuvant therapy, and at surgery (up to 6 months) | Immune profiling of tumor and stromal compartments using histopathology and multi-omics analyses to assess differences between treatment arms and correlation with efficacy. |
| Secondary | Radical resection (R0) | one year | |
| Secondary | Overall survival rate | three year | |
| Secondary | Disease-free survival rate | three year | |
| Secondary | Locoregional recurrence rate | three year | |
| Secondary | Distance metastasis rate | three year |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07898865
GET https://conductscience.org/api/trials/v1/NCT07898865/registered