Trial · NCT07899216
Comparison of Prophylactic Continuous Infusion of Norepinephrine, Ephedrine, and Their Combination for Prevention of Hypotension During Spinal Anaesthesia for Caesarean Delivery
NCT07899216, Not applicable, Active not recruiting, Alexandria University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Comparison of Prophylactic Continuous Infusion of Norepinephrine, Ephedrine, and Their Combination for Prevention of Hypotension During Spinal Anaesthesia for Caesarean Delivery. Trials, record NCT07899216. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07899216
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Comparison of Prophylactic Continuous Infusion of Norepinephrine, Ephedrine, and Their Combination for Prevention of Hypotension During Spinal Anaesthesia for Caesarean Delivery
- NCT number
- NCT07899216
- Status
- Active not recruiting
- Phases
- Not applicable
- Enrollment
- 60 participants, estimated
- Lead sponsor
- Alexandria University
- Conditions
- Maternal Hypotension After Spinal Anesthesia
- Interventions
continuous infusion of noreadrenaline at a fixed rate of 30 ml/min of 4ug/ml, continious ephedrine infusion at a rate of 30 ml/min, Patients will receive a combined infusion of norepinephrine 2 µg/min and ephedrine 2 mg/min.
- First posted
- 2026-10-27
- Last updated
- 2026-10-27
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | The incidence of maternal hypotension from initiation of spinal anaesthesia until end of the opertation . | 60 min after the block | The number of patients who develop hypotension (defined as decreased SBP less than 80% of the baseline reading during the period from intrathecal injection till delivery of the fetus) after spinal block divided by the total number in the group |
| Secondary | 1-Number of hypotensive episodes | 60 min after the block | The number of hypotensive episode experienced by each patient in each group |
| Secondary | 2-Number of rescue vasopressor boluses required | 60 min after the block | Number or rescue doses administrated to each patient when experiencing hypotension defined as SBP less than 80% of the baseline reading |
| Secondary | 3-Incidence of hypertension | 60 min after the block | number of patients who develop intraoperive hypertension (defined as increased systolic blood pressure by more than 20% of the baseline reading) divided by the total number of patients in the group |
| Secondary | 4-Incidence of maternal bradycardia, defined as HR <50 beats/min | 60 min after the block | number of patients who developed bradycardia, defined as HR \<50 beats/min |
| Secondary | 5-Incidence of nausea and vomiting | 60 in after the block | number of patients who developed nausea and vomiting |
| Secondary | 6-Incidence of shivering | 60 in after the block | number of patients who developed shivering |
| Secondary | 7- Any other maternal complications | 60 min after the block | any other maternal complications will be spotted and recorded |
| Secondary | 8-Apgar score | 1 and 5 minutes after the delivery of the baby | APGAR score for detection of the well being of the neonate |
| Secondary | 9-Umbilical arterial pH. | 1 min after the delivery | PH of the blood sample withdrawn from the umbilical cord |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07899216
GET https://conductscience.org/api/trials/v1/NCT07899216/registered