Trial · NCT07900074
Mechanisms of Weight Loss: Tirzepatide vs Semaglutide
NCT07900074, Phase 4, Recruiting, McMaster University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Mechanisms of Weight Loss: Tirzepatide vs Semaglutide. Trials, record NCT07900074. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07900074
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Mechanisms of Weight Loss: Tirzepatide vs Semaglutide
- NCT number
- NCT07900074
- Status
- Recruiting
- Phases
- Phase 4
- Enrollment
- 80 participants, estimated
- Lead sponsor
- McMaster University
- Conditions
- Obesity (Disorder)
- Interventions
- Tirzepatide, Semaglutide
- First posted
- 2026-10-28
- Last updated
- 2026-10-28
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | 24-hour Energy Expenditure Measured Using Whole Room Indirect Calorimetry | Baseline, 12 Weeks | 24-hour energy expenditure will be measured using whole room indirect calorimeter. Metabolic rate in kcal/day will be estimated using the Weir formula, from inspired oxygen and expired carbon dioxide measured every minute by software in the Promethium System, summed over 23 hours and extrapolated to 24 hours by multiplying by 24/23. |
| Secondary | Components of 24-hour Energy Expenditure (EE) | Baseline, 12 Weeks | Resting EE (REE), sleep EE (SEE), diet induced EE (DEE), and activity induced EE (AEE) will be measured using the whole room indirect calorimeter. REE is the intercept of the regression line of EE on activity counts per minute (cpm) determined by accelerometry (i.e., EE at 0 cpm). SEE is defined as the lowest average EE over 3 hours of sleep from 0000h to 0700h and multiplied by 8 to be expressed as kcal/day. DEE is calculated a) as the difference between REE and SEE (this value also includes the energy expended to be awake) and b) as the additional energy expended over 4 hours after breakfast above EE measured at rest first thing in the morning. AEE will be calculated a) as the difference between 24h EE and REE, and b) as the energy expended during a standardized exercise bout in the afternoon. Participants will maintain a cadence of approximately 60 rpm for three 6-minute segments at increasing power. |
| Secondary | Energy Intake | Baseline, 12 Weeks | Energy intake under controlled ad libitum conditions will be assessed by measuring the caloric content of an ad libitum lunch and dinner meals of standardized macronutrient composition provided in the whole room indirect calorimeter. |
| Secondary | Energy Extraction from Food | Baseline, 12 Weeks | To calculate the energy extraction from food passing through the gastrointestinal tract, pills containing nonabsorbable dyes will be ingested at the beginning and end of the 3-day free-living meal plan. Participants will collect all feces from appearance of the first dye until appearance of the second dye. Energy in homogenized feces will be accurately measured in the bomb calorimeter using established procedures. Energy extraction will be calculated as difference between energy intake (based on food provided and returned) and calories in the feces, and will be expressed as kcal/day and a percentage of energy intake. |
| Secondary | Brown Adipose Tissue (BAT) Activity | Baseline, 12 Weeks | To evaluate cold-stimulated BAT activity, MRI scans to quantify proton density fat fraction (PDFF) and T2\* in the supraclavicular region of the neck between the levels of C2/C3 disc and the T4/T5 disc will be performed before and after cold exposure using a full-body water-perfused suit, at 18°C for 1 hour. |
| Secondary | Appetite and Satiety | Baseline, 12 Weeks | Appetite and satiety will be assessed using validated visual scales scored 0-100 before breakfast, 30 minutes later and hourly for 4 hours while in the whole room indirect calorimeter. |
| Secondary | Stool Microbiota Composition | Baseline, 12 Weeks | Stool microbiota analysis completed using 16S rRNA primers will include α-diversity (amplicon sequence variants (ASVs) richness and evenness within each sample) and β-diversity (between samples), and predicted functional metagenomics using PICRUSt or similar software. |
| Secondary | Body Composition | Baseline, 12 Weeks | Body composition will be measured using a dual-energy X-ray absorptiometry (DXA) scan and bioelectrical impedance analysis (BIA). |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07900074
GET https://conductscience.org/api/trials/v1/NCT07900074/registered