Trial · NCT07901322
Cerebello-Cortical Connectivity and Balance Adaptation in Younger and Older Adults
NCT07901322, Not applicable, Not yet recruiting, University of Minnesota
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Cerebello-Cortical Connectivity and Balance Adaptation in Younger and Older Adults. Trials, record NCT07901322. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07901322
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Cerebello-Cortical Connectivity and Balance Adaptation in Younger and Older Adults
- NCT number
- NCT07901322
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 58 participants, estimated
- Lead sponsor
- University of Minnesota
- Conditions
- Aging, Postural Balance, Motor Adaptation
- Interventions
- Transcranial Magnetic Stimulation Assessment, Reactive Balance Adaptation Task
- First posted
- 2026-10-28
- Last updated
- 2026-10-28
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Cerebellar Brain Inhibition (CBI) Ratio | Before and after the reactive balance session, during a single study visit (up to 3 hours). | Cerebellar brain inhibition will be assessed using dual-site, paired-pulse transcranial magnetic stimulation and EMG recordings from the right tibialis anterior muscle. The CBI ratio will be calculated as the mean conditioned peak-to-peak motor-evoked potential amplitude divided by the mean single-pulse motor-evoked potential amplitude for each interstimulus interval. Lower ratios indicate stronger cerebellar inhibition. |
| Primary | Change in Cerebellar TMS-Evoked Potential P80 Amplitude | Before and after the reactive balance session, during a single study visit (up to 3 hours). | The cerebellar TMS-evoked potential P80 will be measured using cerebellar TMS combined with EEG. P80 amplitude will be quantified as the peak EEG potential recorded over the contralateral dorsolateral prefrontal cortex within the 50-90 millisecond interval following TMS. Pre- and post-balance measurements will be compared. |
| Secondary | Cortical Coherence During Reactive Balance Recovery | During the reactive balance testing session, up to 30 minutes | Perturbation-evoked EEG coherence between S1-M1 and PFC-M1 regions. |
| Secondary | Cortical N1 Response and Adaptation | During repeated balance perturbations, up to 30 minutes | Perturbation-evoked EEG N1 response and its adaptation across repeated perturbations. |
| Secondary | Biomechanical Stability Margin | During repeated balance perturbations, up to 30 minutes | Stability margin calculated from the relationship between center-of-pressure and center-of-mass displacement during recovery. |
| Secondary | Reactive Step Threshold | During initial reactive balance testing, up to 30 minutes | Magnitude of support-surface perturbation that elicits a recovery step in approximately 50% of trials. |
| Secondary | Gait Speed | During clinical balance assessment at the single study visit | Gait speed measured using a 10-meter walk test. |
| Secondary | Clinical Balance Performance | During clinical balance assessment at the single study visit | Balance function assessed using the Mini-Balance Evaluation Systems Test (MiniBEST). |
| Secondary | Cognitive Dual-Task Balance Performance | During clinical balance assessment at the single study visit | Balance performance evaluated during dual-task Timed Up and Go and beam-walking assessments. |
| Secondary | Beam Walking Performance | During clinical balance assessment at the single study visit | Distance successfully traversed on a narrow beam under single-task and dual-task conditions. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R21AG101558 | Cerebello-cortical connectivity as an adaptive mechanism for balance control with aging | Palmer, Jacqueline A | UNIVERSITY OF MINNESOTA | NATIONAL INSTITUTE ON AGING | 2026 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07901322
GET https://conductscience.org/api/trials/v1/NCT07901322/registered