Trial · NCT07901725
Linvoseltamab Versus Daratumumab, Bortezomib, Cyclophosphamide, and Dexamethasone (Dara-Vcd) in Adult Participants With Newly Diagnosed Systemic Light Chain Amyloidosis
NCT07901725, Phase 3, Not yet recruiting, Regeneron Pharmaceuticals
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Linvoseltamab Versus Daratumumab, Bortezomib, Cyclophosphamide, and Dexamethasone (Dara-Vcd) in Adult Participants With Newly Diagnosed Systemic Light Chain Amyloidosis. Trials, record NCT07901725. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07901725
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Linvoseltamab Versus Daratumumab, Bortezomib, Cyclophosphamide, and Dexamethasone (Dara-Vcd) in Adult Participants With Newly Diagnosed Systemic Light Chain Amyloidosis
- NCT number
- NCT07901725
- Status
- Not yet recruiting
- Phases
- Phase 3
- Enrollment
- 382 participants, estimated
- Lead sponsor
- Regeneron Pharmaceuticals
- Conditions
- Newly Diagnosed Amyloidosis, Amyloidosis Stage I-IIIA
- Interventions
- Linvoseltamab, Daratumumab, Bortezomib, Cyclophosphamide, Dexamethasone
- First posted
- 2026-10-28
- Last updated
- 2026-10-28
Source ClinicalTrials.gov
Registered outcomes38
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Occurrence of Treatment-Emergent Adverse Events (TEAEs) | Up to 7 years | Part 1 |
| Primary | Severity of TEAEs | Up to 7 years | Part 1 |
| Primary | Occurrence of Adverse Events of Special Interest (AESI) | Up to 7 years | Part 1 |
| Primary | Severity of AESI | Up to 7 years | Part 1 |
| Primary | Occurrence of Serious Adverse Events (SAEs) | Up to 7 years | Part 1 |
| Primary | Severity of SAEs | Up to 7 years | Part 1 |
| Primary | Achievement of Hematologic Complete Response (HemCR) per International Society of Amyloidosis (ISA) response criteria as determined by Blinded Independent Review Committee (BIRC) | Up to 7 years | Part 2 |
| Secondary | Occurrence and timing of grade 2 or 3 Cytokine Release Syndrome (CRS) | Up to 28 days following first dose of linvoseltamab | Part 1 |
| Secondary | Major Organ Deterioration-Progression-Free Survival (MOD-PFS) as determined by BIRC per modified ISA criteria | Up to 7 years | Part 2 |
| Secondary | Overall Survival (OS) | Up to 7 years | Part 2 |
1 to 10 of 38Source ClinicalTrials.gov
See all 38 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07901725
GET https://conductscience.org/api/trials/v1/NCT07901725/registered?page=2