Trial · NCT07903285
Laser-Activated Versus Passive Ultrasonic Irrigation in Endodontic Retreatment
NCT07903285, Not applicable, Not yet recruiting, Inonu University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Laser-Activated Versus Passive Ultrasonic Irrigation in Endodontic Retreatment. Trials, record NCT07903285. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07903285
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Laser-Activated Versus Passive Ultrasonic Irrigation in Endodontic Retreatment
- NCT number
- NCT07903285
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 90 participants, estimated
- Lead sponsor
- Inonu University
- Conditions
- Apical Periodontitis
- Interventions
- Photon-Induced Photoacoustic Streaming, Shock Wave Enhanced Emission Photoacoustic Streaming, Passive Ultrasonic Irrigation
- First posted
- 2026-10-29
- Last updated
- 2026-10-29
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Reduction in Viable Total Cultivable Intracanal Bacterial Load From S2 to S3 | Day 1 (During the single treatment visit, from completion of chemomechanical preparation (S2) to immediately after final irrigant activation (S3).) | Viable total cultivable intracanal bacteria will be quantified by culture as colony-forming units per milliliter (CFU/mL). For each participant, the reduction will be calculated as log10 CFU/mL at S2 minus log10 CFU/mL at S3 and reported in log10 CFU/mL. The reduction will be compared among the PIPS, SWEEPS and passive ultrasonic irrigation groups. S1 denotes sampling after removal of the root canal filling material and before chemomechanical preparation; S2, after chemomechanical preparation and before final irrigant activation; S3, immediately after final irrigant activation. |
| Secondary | Reduction in Viable Total Cultivable Intracanal Bacterial Load From S1 to S2 | Day 1 (During the single treatment visit, from root canal filling removal (S1) to completion of chemomechanical preparation (S2).) | Viable total cultivable intracanal bacteria will be quantified by culture as CFU/mL. For each participant, the reduction will be calculated as log10 CFU/mL at S1 minus log10 CFU/mL at S2 and reported in log10 CFU/mL. This outcome reflects bacterial reduction during the common chemomechanical preparation phase and will be compared among the three groups. S1 denotes sampling after removal of the root canal filling material and before chemomechanical preparation; S2, after chemomechanical preparation and before final irrigant activation; S3, immediately after final irrigant activation. |
| Secondary | Overall Reduction in Viable Total Cultivable Intracanal Bacterial Load From S1 to S3 | Day 1 (During the single treatment visit, from root canal filling removal (S1) to immediately after final irrigant activation (S3).) | Viable total cultivable intracanal bacteria will be quantified by culture as CFU/mL. For each participant, the overall reduction will be calculated as log10 CFU/mL at S1 minus log10 CFU/mL at S3 and reported in log10 CFU/mL. The overall reduction will be compared among the three groups. S1 denotes sampling after removal of the root canal filling material and before chemomechanical preparation; S2, after chemomechanical preparation and before final irrigant activation; S3, immediately after final irrigant activation. |
| Secondary | Reduction in Viable Intracanal Enterococcus faecalis Load From S1 to S2 | Day 1 (During the single treatment visit, from root canal filling removal (S1) to completion of chemomechanical preparation (S2).) | Viable Enterococcus faecalis will be quantified by culture on selective medium (Enterococcosel agar), with suspected colonies confirmed by biochemical tests, and expressed as CFU/mL. For each participant, the reduction will be calculated as log10 CFU/mL at S1 minus log10 CFU/mL at S2 and reported in log10 CFU/mL. The reduction will be compared among the three groups. S1 denotes sampling after removal of the root canal filling material and before chemomechanical preparation; S2, after chemomechanical preparation and before final irrigant activation; S3, immediately after final irrigant activation. |
| Secondary | Reduction in Viable Intracanal Enterococcus faecalis Load From S2 to S3 | Day 1 (During the single treatment visit, from completion of chemomechanical preparation (S2) to immediately after final irrigant activation (S3).) | Viable Enterococcus faecalis will be quantified by culture on selective medium (Enterococcosel agar), with suspected colonies confirmed by biochemical tests, and expressed as CFU/mL. For each participant, the reduction will be calculated as log10 CFU/mL at S2 minus log10 CFU/mL at S3 and reported in log10 CFU/mL. The reduction will be compared among the three groups. S1 denotes sampling after removal of the root canal filling material and before chemomechanical preparation; S2, after chemomechanical preparation and before final irrigant activation; S3, immediately after final irrigant activation. |
| Secondary | Overall Reduction in Viable Intracanal Enterococcus faecalis Load From S1 to S3 | Day 1 (During the single treatment visit, from root canal filling removal (S1) to immediately after final irrigant activation (S3).) | Viable Enterococcus faecalis will be quantified by culture on selective medium (Enterococcosel agar), with suspected colonies confirmed by biochemical tests, and expressed as CFU/mL. For each participant, the overall reduction will be calculated as log10 CFU/mL at S1 minus log10 CFU/mL at S3 and reported in log10 CFU/mL. The overall reduction will be compared among the three groups. S1 denotes sampling after removal of the root canal filling material and before chemomechanical preparation; S2, after chemomechanical preparation and before final irrigant activation; S3, immediately after final irrigant activation. |
| Secondary | Percentage of Participants With Culture-Positive Enterococcus faecalis After Final Irrigant Activation (S3) | Day 1 (Immediately after final irrigant activation (S3), during the single treatment visit.) | A sample will be considered positive if at least one colony is detected on Enterococcosel agar and confirmed as Enterococcus faecalis by biochemical tests. The outcome is reported as the percentage of participants with an E. faecalis-positive S3 sample and will be compared among the three groups. S1 denotes sampling after removal of the root canal filling material and before chemomechanical preparation; S2, after chemomechanical preparation and before final irrigant activation; S3, immediately after final irrigant activation. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers4
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07903285
GET https://conductscience.org/api/trials/v1/NCT07903285/registered