Trial · NCT07903311
Iron Repletion in Cystic Fibrosis
NCT07903311, Phase 4, Not yet recruiting, University of Michigan
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Iron Repletion in Cystic Fibrosis. Trials, record NCT07903311. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07903311
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Iron Repletion in Cystic Fibrosis
- NCT number
- NCT07903311
- Status
- Not yet recruiting
- Phases
- Phase 4
- Enrollment
- 100 participants, estimated
- Lead sponsor
- University of Michigan
- Conditions
- Cystic Fibrosis, Iron Deficiencies, Iron Deficiency Diseases
- Interventions
- IV Repletion, PO Repletion
- First posted
- 2026-10-29
- Last updated
- 2026-10-29
Source ClinicalTrials.gov
Registered outcomes21
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Estimated absolute change in whole blood hemoglobin - ID Cohort | Baseline, and approximately 3 months | Whole blood hemoglobin in g/dL at 3 months after the start of IV versus PO treatment. Full longitudinal study data from all study visits will be modeled in a linear mixed-effects model which will include time from start of treatment, the treatment (IV versus PO), and interactions between the time and treatment at approximately 1, 3, and 6 months. |
| Secondary | Estimated absolute change in whole blood hemoglobin - ID Cohort | Baseline, and approximately 1 and 6 months | Whole blood hemoglobin in g/dL at 1 and 6 months after the start of IV versus PO treatment will be modeled using approaches described in Outcome 1. |
| Secondary | Estimated proportion of non-anemic participants - ID Cohort | Baseline, and approximately 1, 3, and 6 months | Proportion of non-anemic participants over time will be modeled based on an inverse probability weighted generalized estimating equations (GEE) model for the binary variable of hemoglobin value meeting WHO criteria for anemia versus not anemia. |
| Secondary | Estimated relative change in soluble transferrin receptor (sTfR) - ID Cohort | Baseline, and approximately 1, 3, and 6 months | Serum sTfR in % of mg/L at 1, 3, and 6 months will be modeled using approaches described in Outcome 1. |
| Secondary | Estimated absolute change in transferrin saturation (TSAT) - ID Cohort | Baseline, and approximately 1, 3, and 6 months | Serum TSAT in % at 1, 3, and 6 months, determined by total serum iron and iron binding capacity, will be modeled using approaches described in Outcome 1. |
| Secondary | Estimated absolute change in serum iron - ID Cohort | Baseline, and approximately 1, 3, and 6 months | Serum iron in ug/dL at 1, 3, and 6 months will be modeled using approaches described in Outcome 1. |
| Secondary | Estimated absolute change in serum ferritin - ID Cohort | Baseline, and approximately 1, 3, and 6 months | Serum ferritin in ng/mL at 1, 3, and 6 months will be modeled using approaches described in Outcome 1. |
| Secondary | Estimated absolute change in serum ferritin(adj-factor) - ID Cohort | Baseline, and approximately 1, 3, and 6 months | Adjusted serum ferritin using the correction factor method for C-reactive protein (CRP) in ng/mL at 1, 3, and 6 months will be modeled using approaches described in Outcome 1. |
| Secondary | Estimated absolute change in serum ferritin(adj-BRINDA) - ID Cohort | Baseline, and approximately 1, 3, and 6 months | Adjusted serum ferritin using the BRINDA method for CRP in ng/mL at 1, 3, and 6 months will be modeled using approaches described in Outcome 1. |
| Secondary | Estimated absolute change in sTfR index - ID Cohort | Baseline, and approximately 1, 3, and 6 months | sTfR index calculated by sTfR / log (ferritin) at 1, 3, and 6 months will be modeled using approaches described in Outcome 1. |
1 to 10 of 21Source ClinicalTrials.gov
See all 21 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| K23HL175126 | Iron Deficiency in Cystic Fibrosis: Characterization of Clinical Impact and Treatment Effects | JIA, SHIJING | UNIVERSITY OF MICHIGAN AT ANN ARBOR | NATIONAL HEART, LUNG, AND BLOOD INSTITUTE | 2025 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07903311
GET https://conductscience.org/api/trials/v1/NCT07903311/registered?page=2