Trial · NCT07904208
Oral GDC-0077 in Premature Ovarian Insufficiency
NCT07904208, Phase 1, Not yet recruiting, Women's Hospital School Of Medicine Zhejiang University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Oral GDC-0077 in Premature Ovarian Insufficiency. Trials, record NCT07904208. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07904208
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Oral GDC-0077 in Premature Ovarian Insufficiency
- NCT number
- NCT07904208
- Status
- Not yet recruiting
- Phases
- Phase 1
- Enrollment
- 12 participants, estimated
- Lead sponsor
- Women's Hospital School Of Medicine Zhejiang University
- Conditions
- Primary Ovarian Insufficiency
- Interventions
- GDC-0077
- First posted
- 2026-10-29
- Last updated
- 2026-10-29
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Incidence of treatment-emergent adverse events (TEAEs), including hyperglycemia, stomatitis/mucositis, and diarrhea | 3 months | Proportion of participants experiencing any TEAE, serious adverse event (SAE), and AEs of special interest (fasting glucose elevation, oral stomatitis/mucositis, diarrhea), graded by CTCAE v5.0. Fasting glucose will be monitored weekly during the first month after treatment initiation; other AEs will be captured throughout the 3-month follow-up. |
| Primary | Change in total antral follicle count (AFC) from baseline to 3 months after treatment initiation | Baseline and 3 months | Total AFC (both ovaries) assessed by transvaginal ultrasound. Baseline AFC will be recorded during screening (D-28 to D-1). |
| Secondary | Proportion of participants with ≥1 antral follicle | Baseline and 3 months | Measured by ultrasound |
| Secondary | Proportion of participants with ≥1 dominant follicle | Baseline and 3 months | Measured by ultrasound |
| Secondary | Change in ovarian volume | Baseline and 3 months | Measured by ultrasound |
| Secondary | Change in serum FSH, LH levels (IU/L) | Baseline and 3 months | Change in serum FSH, LH levels (IU/L) |
| Secondary | Proportion of participants achieving FSH <25 IU/L | 3 months | Proportion of participants achieving FSH \<25 IU/L |
| Secondary | Proportion of participants with ≥1 spontaneous menses (non-HRT-induced) | 3 months | Proportion of participants with ≥1 spontaneous menses (non-HRT-induced) |
| Secondary | IVF outcomes, if applicable: oocytes retrieved, transferable embryos, good-quality embryos, pregnancy outcomes | through study completion, an average of 1 year | IVF outcomes, if applicable: oocytes retrieved, transferable embryos, good-quality embryos, pregnancy outcomes |
| Secondary | Change in serum E2 levels (pmol/L) | Baseline and 3 months | Change in serum E2 levels (pmol/L) |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07904208
GET https://conductscience.org/api/trials/v1/NCT07904208/registered