Trial · NCT07904507
A Comparison of Beta-blockers and Calcium Channel Blockers in Atrial Fibrillation
NCT07904507, Phase 4, Not yet recruiting, University Hospital, Basel, Switzerland
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Comparison of Beta-blockers and Calcium Channel Blockers in Atrial Fibrillation. Trials, record NCT07904507. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07904507
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Comparison of Beta-blockers and Calcium Channel Blockers in Atrial Fibrillation
- NCT number
- NCT07904507
- Status
- Not yet recruiting
- Phases
- Phase 4
- Enrollment
- 266 participants, estimated
- Lead sponsor
- University Hospital, Basel, Switzerland
- Conditions
- Atrial Fibrillation (AF)
- Interventions
- Experimental intervention, Control Intervention
- First posted
- 2026-10-29
- Last updated
- 2026-10-29
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Atrial-Fibrillation-related Quality of Life | From baseline to 3 months | Change in Atrial-Fibrillation-related Quality of Life between Non-dihydropyridine calcium channel blockers (NDCC) versus continuation of beta-blockers (BB) from baseline to 3 months in patients with Atrial-Fibrillation. The primary outcome uses the AFEQT questionnaire: The AFEQT 20-item questionnaire is a validated, AF-specific QoL tool. It assesses 4 domains: symptoms, daily activities, treatment concerns, and treatment satisfaction. The overall AFEQT score is calculated using the first 3 domains and ranges from 0 = worst to 100 = best QoL. Additionally, for each domain of interest, there is a corresponding subscale score: symptoms, daily activities, treatment concerns, and treatment satisfaction subscale scores. Each subscale ranges from 0 = worst to 100 = best QoL and is scored separately. The AFEQT questionnaire will be done at baseline before the intake of the first study drug and after three months of intervention. |
| Secondary | NT-proBNP | At Baseline and after 3 Months | Change in NT-proBNP levels measured at baseline and after 3 months. NT-proBNP is released into the circulation in response to myocardial cell stretch. This biomarker is commonly used to evaluate the degree of heart failure in cardiac patients. Non-fasting blood samples will be taken at baseline before randomization and at the final study visit (4.7ml each). NT-proBNP levels will be measured in the laboratory of the respective study site by using an electrochemiluminescence immunoassay (Elecsys, Roche Diagnostics, Switzerland). Furthermore, if patients provide consent, additional blood samples (serum, plasma and whole blood) will be taken, processed, frozen and stored at -80°C, according to the ethical guidelines concerning biobanking, at the Cardiovascular Research Institute Basel. These samples will be used for future genetic analyses and for the assessment of emerging biomarkers of interest in this context. |
| Secondary | 6-minute walking test (6MWT) distance | At baseline and after 3 months | Change in 6MWT distance assessed at baseline and after 3 months The 6MWT is a simple test which does not require expensive equipment or advanced training for technicians. The test involves asking the patient to walk the longest distance possible in a set interval of 6 minutes, through a walking course (corridor) preferably 30 meters long. The result of the 6MWT will be entered in the CRF as the distance in meters. In this context, other variables will be assessed, including the Borg Scale after the test and information on whether the test was done with a walking aid or must be terminated earlier. The 6MWT will be done at baseline before randomization and after 3 months of intervention. |
| Secondary | Peak flow measurement | At baseline and after 3 months | Change in peak flow measured at baseline and at the study end visit after 90 days of study intervention. The patient will perform the test in a standing position. Study personnel will instruct the patient to inhale as deeply as possible and then exhale as forcefully and rapidly as they can. The measurement will be repeated three times, and the results of all three attempts will be recorded in the study database. |
| Secondary | Hierarchical composite endpoint comprising | Baseline to 3 months | A hierarchical win ratio will be calculated comparing participants between treatment groups using the following pre-specified hierarchy (in order of priority), all assessed as change from baseline to 3 months: * AF-related QoL * 6MWT distance * NT-proBNP |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07904507
GET https://conductscience.org/api/trials/v1/NCT07904507/registered