Trial · NCT07904949
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament Reconstruction
NCT07904949, Not applicable, Not yet recruiting, Peking University Third Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament Reconstruction. Trials, record NCT07904949. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07904949
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament Reconstruction
- NCT number
- NCT07904949
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 144 participants, estimated
- Lead sponsor
- Peking University Third Hospital
- Conditions
- Anterior Cruciate Ligament Injuries, Recovery Quality, Auricular Vagus Nerve Stimulation
- Interventions
- Experimental-Active taVNS, Sham transcutaneous auricular vagus nerve stimulation
- First posted
- 2026-10-29
- Last updated
- 2026-10-29
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Quality of Recovery-15 (QoR-15) score | 24 hours after surgery | Validated 15-item patient-reported questionnaire assessing postoperative recovery quality. Total score ranges from 0-150; higher score indicates better postoperative recovery quality. |
| Secondary | Cumulative oral morphine equivalent (OME) consumption of rescue analgesics | 0 to 24 hours after surgery | Total cumulative rescue opioid analgesic consumption converted to oral morphine equivalent (OME) over the observation period. |
| Secondary | Time to first rescue analgesic requirement | Within 24 hours after surgery | Time interval from the end of surgery to the first administration of rescue analgesic medication for pain. |
| Secondary | Resting NRS pain score (0-10; higher=worse pain) | 0, 4, 8, 12, and 24 hours after surgery | Numeric Rating Scale (NRS) for pain; score range 0-10, 0 = no pain, 10 = worst imaginable pain; assessed at rest. |
| Secondary | Activity-evoked NRS pain score (passive knee flexion 45°) | 4, 8, 12, and 24 hours after surgery | Numeric Rating Scale (NRS) for pain (0-10; higher score = worse pain). Pain elicited by standardized passive knee flexion to 45 degrees. Not evaluable if regional block has not resolved. |
| Secondary | Maximal NRS pain score | 0 to 24 hours after surgery | The highest observed Numeric Rating Scale pain score within the observation window (resting pain). Score range 0-10; higher score represents worse pain. |
| Secondary | Time to first standardized out-of-bed mobilization | From the end of surgery until hospital discharge, approximately 1 day after surgery | Time interval from the end of surgery until completion of the first standardized out-of-bed mobilization (sitting, standing and walking ≥3 m under assistance). |
| Secondary | Post-operative night sleep quality score (0-10; higher=better sleep) | During the first night after surgery | Patient-reported sleep quality score, range 0-10; 0 = extremely poor sleep, 10 = excellent sleep. Assessed for the first night after surgery. |
| Secondary | Incidence of opioid-related adverse events (PONV, pruritus, urinary retention, over-sedation, respiratory depression) | 0 to 24 hours after surgery | Number / proportion of participants experiencing at least one opioid-related adverse event including postoperative nausea and vomiting (PONV), pruritus, urinary retention, over-sedation, respiratory depression. |
| Secondary | Incidence of intervention-related adverse events (ear pain, erythema, dizziness, palpitation) | During stimulation sessions and the first 24 hours after surgery | Number / proportion of participants experiencing adverse events related to taVNS intervention: ear pain, local skin erythema, dizziness, palpitation. |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers3
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07904949
GET https://conductscience.org/api/trials/v1/NCT07904949/registered