Trial · NCT07905209
Evaluation of MTHFR and DNMT3B Gene Polymorphisms Along With Periodontal Clinical Parameters in Healthy Individuals and Individuals With Type 2 Diabetes and Periodontitis
NCT07905209, Active not recruiting, Akdeniz University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Evaluation of MTHFR and DNMT3B Gene Polymorphisms Along With Periodontal Clinical Parameters in Healthy Individuals and Individuals With Type 2 Diabetes and Periodontitis. Trials, record NCT07905209. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07905209
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Evaluation of MTHFR and DNMT3B Gene Polymorphisms Along With Periodontal Clinical Parameters in Healthy Individuals and Individuals With Type 2 Diabetes and Periodontitis
- NCT number
- NCT07905209
- Status
- Active not recruiting
- Enrollment
- 200 participants, actual
- Lead sponsor
- Akdeniz University
- Conditions
- Periodontitis, Type 2 Diabetes Mellitus (DM)
- Interventions
- MTHFR and DNMT3B Genetic Polymorphism Analysis
- First posted
- 2026-10-29
- Last updated
- 2026-10-29
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | MTHFR C677T (rs1801133) Genotype Distribution | At baseline (single blood sample collection) | The distribution of MTHFR C677T (rs1801133) genotypes (CC, CT, and TT) will be determined using DNA extracted from venous blood samples. Genotype frequencies will be compared among the four study groups: healthy individuals, individuals with type 2 diabetes mellitus only, individuals with periodontitis only, and individuals with both conditions. |
| Primary | MTHFR A1298C (rs1801131) Genotype Distribution | At baseline (single blood sample collection) | The distribution of MTHFR A1298C (rs1801131) genotypes (AA, AC, and CC) will be determined using DNA extracted from venous blood samples. Genotype frequencies will be compared among four study groups: healthy individuals, individuals with type 2 diabetes mellitus only, individuals with periodontitis only, and individuals with both type 2 diabetes mellitus and periodontitis. |
| Primary | DNMT3B -149C>T (rs2424913) Genotype Distribution | At baseline (single blood sample collection) | The distribution of DNMT3B -149C\>T (rs2424913) genotypes (CC, CT, and TT) will be determined using DNA extracted from venous blood samples. Genotype frequencies will be compared among four study groups: healthy individuals, individuals with type 2 diabetes mellitus only, individuals with periodontitis only, and individuals with both type 2 diabetes mellitus and periodontitis. |
| Secondary | Plaque Index (PI) Score | At baseline (single periodontal examination) | Plaque accumulation will be assessed using the Plaque Index (PI). The PI score will be recorded during the baseline periodontal examination and compared among four study groups: healthy individuals, individuals with type 2 diabetes mellitus only, individuals with periodontitis only, and individuals with both type 2 diabetes mellitus and periodontitis. |
| Secondary | Gingival Index (GI) Score | At baseline (single periodontal examination) | Gingival inflammation will be assessed using the Gingival Index (GI). The GI score will be recorded during the baseline periodontal examination and compared among four study groups: healthy individuals, individuals with type 2 diabetes mellitus only, individuals with periodontitis only, and individuals with both type 2 diabetes mellitus and periodontitis. |
| Secondary | Probing Pocket Depth (PPD) | At baseline (single periodontal examination) | Probing Pocket Depth (PPD) will be measured in millimeters (mm) using a periodontal probe during the baseline periodontal examination. PPD values will be compared among four study groups: healthy individuals, individuals with type 2 diabetes mellitus only, individuals with periodontitis only, and individuals with both type 2 diabetes mellitus and periodontitis. |
| Secondary | Clinical Attachment Loss (CAL) | At baseline (single periodontal examination) | Clinical Attachment Loss (CAL) will be measured in millimeters (mm) as the distance from the cementoenamel junction to the base of the periodontal pocket using a periodontal probe. CAL values will be recorded during the baseline periodontal examination and compared among four study groups: healthy individuals, individuals with type 2 diabetes mellitus only, individuals with periodontitis only, and individuals with both type 2 diabetes mellitus and periodontitis. |
| Secondary | Gingival Recession (GR) | At baseline (single periodontal examination) | Gingival Recession (GR) will be measured in millimeters (mm) as the distance from the cementoenamel junction to the gingival margin using a periodontal probe. GR values will be recorded during the baseline periodontal examination and compared among four study groups: healthy individuals, individuals with type 2 diabetes mellitus only, individuals with periodontitis only, and individuals with both type 2 diabetes mellitus and periodontitis. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers3
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07905209
GET https://conductscience.org/api/trials/v1/NCT07905209/registered