Trial · NCT07908030
Curcumin Extract Added to Ciprofloxacin for Typhoid Carriers Among Food Handlers of the Free Nutritious Meal Program
NCT07908030, Phase 2, Not yet recruiting, Universitas Sebelas Maret
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Curcumin Extract Added to Ciprofloxacin for Typhoid Carriers Among Food Handlers of the Free Nutritious Meal Program. Trials, record NCT07908030. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07908030
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Curcumin Extract Added to Ciprofloxacin for Typhoid Carriers Among Food Handlers of the Free Nutritious Meal Program
- NCT number
- NCT07908030
- Status
- Not yet recruiting
- Phases
- Phase 2
- Enrollment
- 100 participants, estimated
- Lead sponsor
- Universitas Sebelas Maret
- Conditions
- Typhoid Carrier, Typhoid Fever, Salmonella Typhi Infection
- Interventions
- Curcumin extract, Ciprofloxacin, Placebo
- First posted
- 2026-10-30
- Last updated
- 2026-10-30
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Proportion of participants with negative Salmonella Typhi culture (eradication) | 30 days after the end of the 28-day treatment | A rectal swab is cultured on Salmonella Shigella Agar. Suspected colonies are confirmed with IMViC biochemical tests. Eradication means no growth of Salmonella Typhi. The proportion is compared between the two arms. |
| Secondary | Treatment adherence | Day 1 to day 28 of treatment | Percentage of prescribed capsules taken. Measured by pill count and a daily intake log. Adherence above 90% is counted as good adherence. |
| Secondary | Number of participants with adverse events | From the first dose to 30 days after the end of the 28-day treatment | Adverse events are recorded at each monitoring visit. They include gastrointestinal complaints, skin reactions, and any other event reported by the participant or found by the investigator. |
| Secondary | Prevalence of typhoid carriage among screened food handlers | At screening (stage 1, before randomization) | Number of food handlers with culture-confirmed Salmonella Typhi carriage divided by the number of food handlers screened, expressed as a percentage. |
| Other | Positive predictive value of the Widal test for culture-confirmed carriage | At screening (stage 1, before randomization) | Proportion of participants with a Vi or O/H Widal titer above 1/160 who have a positive rectal swab culture for Salmonella Typhi. |
| Other | Fluoroquinolone susceptibility of Salmonella Typhi isolates | At screening (stage 1, before randomization) | Number of isolates that are susceptible, intermediate, or resistant to ciprofloxacin and other fluoroquinolones on antimicrobial susceptibility testing. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07908030
GET https://conductscience.org/api/trials/v1/NCT07908030/registered