Trial · NCT07908251
a Novel siRNA Eyedrops for DED Treatment
NCT07908251, Early phase 1, Not yet recruiting, Eye & ENT Hospital of Fudan University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. a Novel siRNA Eyedrops for DED Treatment. Trials, record NCT07908251. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07908251
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- a Novel siRNA Eyedrops for DED Treatment
- NCT number
- NCT07908251
- Status
- Not yet recruiting
- Phases
- Early phase 1
- Enrollment
- 30 participants, estimated
- Lead sponsor
- Eye & ENT Hospital of Fudan University
- Conditions
- Dry Eye
- Interventions
- Low dose Arm, High dose Arm, Placebo Arm
- First posted
- 2026-11-02
- Last updated
- 2026-11-02
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change From Period Baseline to Week 4 in Total Corneal Fluorescein Staining | Week 0 and Week 4 (Period 1); Week 8 and Week 12 (Period 2). | Total corneal fluorescein staining (tCFS) will be assessed at the beginning and end of each 4-week treatment period. The change from the period-specific baseline to the end of each treatment period will be calculated. Results will be summarized according to the treatment received (low-dose, high-dose, or placebo), using data from both treatment periods. |
| Primary | the proportion of CFS responders (defined as ≥3-grade improvement in CFS score) | Week 0 and Week 4 (Period 1); Week 8 and Week 12 (Period 2). | |
| Primary | Number of Participants With Treatment-Emergent Ocular Adverse Events | Week 0 and Week 4 (Period 1); Week 8 and Week 12 (Period 2). | Ocular safety will be assessed by recording treatment-emergent ocular adverse events during each 4-week treatment period. The number and percentage of participants experiencing at least one ocular adverse event will be summarized separately for the low-dose, high-dose, and placebo treatments, using data from both treatment periods according to the treatment received. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07908251
GET https://conductscience.org/api/trials/v1/NCT07908251/registered