Trial · NCT07909486
Identification of Biomarkers for Vagus Nerve Stimulation in Patients With Refractory Epilepsy
NCT07909486, Not applicable, Recruiting, Cliniques universitaires Saint-Luc- Université Catholique de Louvain
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Identification of Biomarkers for Vagus Nerve Stimulation in Patients With Refractory Epilepsy. Trials, record NCT07909486. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07909486
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Identification of Biomarkers for Vagus Nerve Stimulation in Patients With Refractory Epilepsy
- NCT number
- NCT07909486
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 20 participants, estimated
- Lead sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Conditions
- Refractory Epilepsy
- Interventions
- Vagus nerve stimulation
- First posted
- 2026-11-02
- Last updated
- 2026-11-05
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Pupillometry | Before Implantation, 3 Months, and 6 Months Post Implantation | Using an eye-tracking camera, the investigators will record pupil dilation responses (PDR) induced by both VNS and an oddball paradigm. The PDR signals (measured in arbitrary units and converted to mm) will be aligned with the corresponding stimulus in order to extract the trials. From these, classical PDR metrics such as peak amplitude or latency can be derived. |
| Primary | P300 | Before Implantation, 3 Months, and 6 Months Post Implantation | The P300 component of the evoked potential can be extracted from electroencephalography (EEG) signals as a wave peaking around 300 ms after a given stimulus. An auditory oddball paradigm will be employed as the stimulus. Then, classical metrics will be derived from the P300, such as amplitude and latency. |
| Primary | LMEP | Before Implantation, 3 Months, and 6 Months Post Implantation | The investigators aim to record a reproducible and quantifiable VNS-induced laryngeal motor-evoked potential (LMEP) from the electromyography (EMG) signal at the larynx level. After filtering the signal, the relevant component that is expected to be observed consists of the artefacts generated by the ON periods of the VNS - each VNS pulse will contain a laryngeal response, which appears right after the VNS pulse. With this laryngeal response detected, the LMEP will be characterised by quantitative features including peak amplitude (μV) and latency (ms). |
| Secondary | Response assessment | 6 months | At 6 months, the seizure frequency reduction will be evaluated compared to 3 months before implantation. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests1
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as |
|---|---|
| Oddball Target Detection | Primary outcome |
Source ConductCognition
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07909486
GET https://conductscience.org/api/trials/v1/NCT07909486/registered