Trial · NCT07909525
Addressing Financial Hardship in AYA Cancer Survivors Through the Use of the New LIFT UP Intervention
NCT07909525, Not applicable, Not yet recruiting, ECOG-ACRIN Cancer Research Group
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Addressing Financial Hardship in AYA Cancer Survivors Through the Use of the New LIFT UP Intervention. Trials, record NCT07909525. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07909525
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Addressing Financial Hardship in AYA Cancer Survivors Through the Use of the New LIFT UP Intervention
- NCT number
- NCT07909525
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 448 participants, estimated
- Lead sponsor
- ECOG-ACRIN Cancer Research Group
- Conditions
- Breast Ductal Carcinoma In Situ, Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
- Interventions
- Best Practice, Educational Intervention, Informational Intervention, Interview, Survey Administration
- First posted
- 2026-11-02
- Last updated
- 2026-11-02
Source ClinicalTrials.gov
Registered outcomes17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change of financial hardship | Baseline up to 6 months after randomization | Will be measured by Comprehensive Score for Financial Toxicity (FACIT-COST). Will calculate the difference in COST from baseline to 6-month follow-ups for adolescents and young adults (AYA) participants who provide data at each time point and use two-sample t-tests (two sided) to assess if mean differences are significantly different between arms. If the data are not normally distributed, nonparametric methods (e.g., Wilcoxon rank-sum test) will be used to assess the difference. To control for confounders, will fit linear regressions with the change of COST from baseline to 6-month follow-up as the response variable and age, race/ethnicity, socioeconomic status, disease type, sex, and other social determinants of health as covariates. Will stratify analysis by age stratum (18-25 years-old versus \[vs\] 26-39 years-old), sex, and race to minimize bias. |
| Primary | Change in health insurance literacy | Baseline up to 6 months after randomization | Will be measured by the Health Insurance Literacy Measure (HILM). The HILM co-primary endpoint will be analyzed restricted to AYA participants insured at baseline (modified intention to treat \[ITT\] for HILM), AYA participants with valid HILM-9 scores at baseline and 6 months. An ITT analysis using multiple imputation will be performed to handle missing HILM scores (including those for uninsured participants), with insurance status and other prespecified covariates included in the imputation model. |
| Secondary | Change of self-reported material financial hardship | Baseline up to 6 months after randomization | Will be assessed using Childhood Cancer Survivor Study Long-Term Follow-Up Survey that assess material subdomains of financial hardship. |
| Secondary | Change of self-reported psychological financial hardship | Baseline up to 6 months after randomization | Psychological financial hardship will be assessed using the applicable CCSS Long-Term Follow-Up Health Insurance Survey items. Item responses will be aggregated into a single domain-level ordinal measure based on the number of psychological hardship instances reported: 0, 1-2, or ≥3 instances. Change from baseline to 6 months will be compared between randomized arms. |
| Secondary | Change of self-reported behavioral aspects of financial hardship | Baseline up to 6 months after randomization | Behavioral financial hardship will be assessed using the 10 behavioral hardship items from the CCSS Long-Term Follow-Up Health Insurance Survey. Item responses will be aggregated into a single domain-level ordinal measure based on the number of behavioral hardship instances reported: 0, 1-2, or ≥3 instances. Change from baseline to 6 months will be compared between randomized arms. |
| Secondary | Change of self-reported material financial hardship | Baseline up to 12 months after randomization | Material financial hardship will be assessed using the 9 material hardship items from the CCSS Long-Term Follow-Up Health Insurance Survey. Item responses will be aggregated into a single domain-level ordinal measure based on the number of material hardship instances reported: 0, 1-2, or ≥3 instances. Longitudinal change in this measure from baseline through 12 months will be compared between randomized arms. |
| Secondary | Change of self-reported psychological financial hardship | Baseline up to 12 months after randomization | Psychological financial hardship will be assessed using the applicable CCSS Long-Term Follow-Up Health Insurance Survey items. Item responses will be aggregated into a single domain-level ordinal measure based on the number of psychological hardship instances reported: 0, 1-2, or ≥3 instances. Longitudinal change in this measure from baseline through 12 months will be compared between randomized arms. |
| Secondary | Change of self-reported behavioral aspects of financial hardship | Baseline up to 12 months after randomization | Behavioral financial hardship will be assessed using the 10 behavioral hardship items from the CCSS Long-Term Follow-Up Health Insurance Survey. Item responses will be aggregated into a single domain-level ordinal measure based on the number of behavioral hardship instances reported: 0, 1-2, or ≥3 instances. Longitudinal change in this measure from baseline through 12 months will be compared between randomized arms. |
| Secondary | Barriers and facilitators of LIFT UP implementation | Up to 13 months after randomization | Assessed via qualitative interviews with AYA participants and non-patient participants. Analysis will be guided by a codebook informed by the Consolidated Framework for Implementation Research and the Theoretical Domains Framework and conducted in Atlas.ti, a multifunctional qualitative data analysis software |
| Other | Proportion of application and approval for financial assistance | At 3, 6, and 12 months after randomization | Will be assessed using Supportive Services (Consumer Cancer Care) questionnaire. The proportions of applications and approval for financial assistance will be calculated at 3-, 6-, and 12-month follow up time points by arm. |
1 to 10 of 17Source ClinicalTrials.gov
See all 17 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants2
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|---|---|---|---|---|---|
| R01CA282653 | Addressing financial hardship in adolescent and young adult cancer survivors: Efficacy and implementation of a multilevel intervention in community-based oncology practices | SALSMAN, JOHN; BIRKEN, SARAH ABIGAIL | WAKE FOREST UNIVERSITY HEALTH SCIENCES | NATIONAL CANCER INSTITUTE | 2024 to 2025 | NIH RePORTER |
| UG1CA189828 | ECOG-ACRIN NCORP Research Base | WAGNER, LYNNE I.; ODWYER, PETER J; SCHNALL, MITCHELL D. | ECOG-ACRIN MEDICAL RESEARCH FOUNDATION | NATIONAL CANCER INSTITUTE | 2014 to 2025 | NIH RePORTER |
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07909525
GET https://conductscience.org/api/trials/v1/NCT07909525/registered