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Trial · NCT07910396

Registered outcomes23

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

ListOutcomeTime frameDescription
OtherResting-State Functional Connectivity Between the CMN Target and Cortical SCANBaseline (Visit 1 MRI, before Arm 1)
Functional connectivity between the individualized CMN target and the participant\'s cortical Somato-Cognitive Action Network (SCAN) regions, computed from baseline resting-state fMRI as the Fisher z-transformed Pearson correlation of their time series (unitless; higher values indicate stronger connectivity).
OtherMinutes of Usable Resting-State fMRI Data After Motion CensoringBaseline (Visit 1 MRI, before Arm 1)Minutes of resting-state fMRI data retained after removing frames with framewise displacement of 0.2 mm or greater.
OtherCorrelation Between Baseline CMN-SCAN Functional Connectivity and Pain Response to Focused CMN LIFUBaseline MRI (Visit 1) and Days 6 to 7 after each treatment arm
Spearman correlation coefficient (range -1 to 1) between (1) baseline CMN-to-cortical SCAN functional connectivity (Fisher z-transformed Pearson correlation, measured using (1) baseline resting-state fMRI and (2) change in daily Brief Pain Inventory pain intensity (0 to 10 scale; mean of current, worst, least and average pain) from the pre-arm baseline to Days 6 to 7 after the focused CMN LIFU arm, relative to the same change after unfocused control LIFU.

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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