Trial · NCT07910552
The Immunobiological Mechanisms of Depression in Perimenopause
NCT07910552, Recruiting, Van Andel Research Institute
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Immunobiological Mechanisms of Depression in Perimenopause. Trials, record NCT07910552. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07910552
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Immunobiological Mechanisms of Depression in Perimenopause
- NCT number
- NCT07910552
- Status
- Recruiting
- Enrollment
- 120 participants, estimated
- Lead sponsor
- Van Andel Research Institute
- Conditions
- Perimenopause, Major Depressive Episode (MDE)
- First posted
- 2026-11-02
- Last updated
- 2026-11-02
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Inflammatory markers | Inflammatory markers will be measured at baseline and the follow up time point: 8 weeks after the first visit for the depressed group. | IL-1-33 and acute phase reactants ICAM, VCAM, CRP, SAA) will be measured using high-sensitivity ELISAs, Mesoscale platform or Luminex platforms |
| Primary | thyroid status, hormonal status | At the baseline and follow up visit (8 weeks) | Measure estrogen, progesterone, luteinizing hormone and follicle stimulating hormone, cortisol levels for controlling their interactions with cytokines and AhR ligands. |
| Primary | glucose levels | At the baseline and follow up visit (8 weeks) | For controlling interactions with hormones and cytokines, AhR ligands. |
| Primary | hemoglobin levels | At the baseline and follow up visit (8 weeks) | For controlling interactions with hormones and cytokines, AhR ligands. |
| Secondary | RNA sequencing | At baseline | Assess gene expression levels |
| Secondary | methylation analysis | At baseline | Assess genome-wide methylation levels |
| Secondary | ATAC sequencing | At baseline | ATAC sequencing on the naïve T-cells to assess chromatin accessibility. |
| Secondary | FACS profiling | until the end of the study | sorting and staining of lymphocytes to identify immune cell profile changes |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers34
The papers the trial lists on ClinicalTrials.gov.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R01MH139201 | The immunobiological mechanisms of depression in perimenopause | BRUNDIN, LENA CECILIA; ACHTYES, ERIC DANIEL; OSBORNE, LAUREN M; YOUSSEF, NAGY A. | VAN ANDEL RESEARCH INSTITUTE | NATIONAL INSTITUTE OF MENTAL HEALTH | 2025 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07910552
GET https://conductscience.org/api/trials/v1/NCT07910552/papers?page=2