Trial · NCT07910786
MetAbolic Changes in the SepSis LIVEr
NCT07910786, Not applicable, Completed, University Hospital, Ghent
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. MetAbolic Changes in the SepSis LIVEr. Trials, record NCT07910786. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07910786
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- MetAbolic Changes in the SepSis LIVEr
- NCT number
- NCT07910786
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 23 participants, actual
- Lead sponsor
- University Hospital, Ghent
- Conditions
- Sepsis, Peritonitis; Acute
- Interventions
- Liver biopsy, blood sampling
- First posted
- 2026-11-02
- Last updated
- 2026-11-02
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | To study whether septic peritonitis patients have alterations in the expression levels of inflammatory genes linked to reduced activity of GR and PPARa in liver tissue. | Day 0 | Evaluation of the expression levels of inflammatory genes linked to a reduced GR and PPARa activity. Compare these gene expressions with control livers. |
| Primary | To study whether human sepsis liver samples show an accumulation of FFA and alterations in collagen in liver. | Day 0 | Lipid and collagen staining in liver samples. This will be done with an immunostaining with Lipidtox (Life Technologies) and Picrosirius Red/Masson Trichrome. |
| Primary | To study whether there are indications for reduced activity of GR and PPARa in blood plasma. | up to day 7 | Metabolites measurements in plasma (glucose/lactate/glycerol/FFA). These blood parameters can be indicative for GR and PPARa activity in the liver. |
| Primary | To study whether there is a correlation between reduced GR/PPARa activity in the liver during sepsis and the general status of the septic patient (SOFA score), inflammatory markers such as IL6, TNF, procalcitonin, corticosterone or other metabolites. | up to day 30 | Inflammation markers (corticosterone, IL6, TNF, procalcitonin) and other metabolites in plasma, as well as SOFA score will be linked with GR/PPARa functioning in the liver. |
| Primary | To study whether septic peritonitis patients have alterations in the expression levels of metabolic genes linked to reduced activity of GR and PPARa in liver tissue. | Day 0 | Evaluation of the expression levels of inflammatory genes and metabolic genes linked to a reduced GR and PPARa activity. Compare these gene expressions with control livers. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers7
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07910786
GET https://conductscience.org/api/trials/v1/NCT07910786/registered