Trial · NCT07911033
Relationship Between Insulin Dose and Complications in Type 1 Diabetes
NCT07911033, Not yet recruiting, Rachel Miller
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Relationship Between Insulin Dose and Complications in Type 1 Diabetes. Trials, record NCT07911033. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07911033
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Relationship Between Insulin Dose and Complications in Type 1 Diabetes
- NCT number
- NCT07911033
- Status
- Not yet recruiting
- Enrollment
- 80 participants, estimated
- Lead sponsor
- Rachel Miller
- Conditions
Diabetes Mellitus, Type 1 Diabetes, Cardiovascular Diseases (CVD), Severe Albuminuria, Estimated Glomerular Filtration Rate (eGFR), Hypoglycemia (Diabetic), Vascular Calcification, Carotid-femoral Pulse Wave Velocity, Kidney Diseases
- Interventions
- Routine/prescribed exogenous insulin dose
- First posted
- 2026-11-02
- Last updated
- 2026-11-02
Source ClinicalTrials.gov
Registered outcomes17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Time to First Total Composite Cardiovascular Disease (CVD) Endpoint | Up to 37 years. | Time from study baseline to the first instance of CVD death, myocardial infarction (MI), coronary revascularization, blockage ≥50%, ischemic ECG at study visit, study physician-diagnosed angina, or stroke. Participants not experiencing CVD will be censored at their last event-free follow-up. |
| Primary | Time to First Instance of Severely Increased Albuminuria (SIA) | Up to 30 years. | Time from study baseline to the first instance of albumin excretion rate ≥200 µg/min or albumin-creatinine ratio ≥300 mg/g in ≥2 of 3 timed urine specimens (24-hour, overnight, 4 hour clinic specimen). Participants not experiencing SIA will be censored at their last event-free follow-up. |
| Primary | Time to Sustained Estimated Glomerular Filtration Rate (eGFR) Decline | Up to 30 years. | Time from study baseline to the first instance of two consecutive visits with eGFR\<60 ml/min/1.73m\^2. Participants not experiencing sustained eGFR decline will be censored at their last event-free follow-up. |
| Primary | Proportion of Participants Experiencing Level 3 Hypoglycemia | Up to 37 years. | Count of severe hypoglyemia events characterized by altered mental and/or physical status requiring assistance. |
| Primary | Coronary Artery Calcification (CAC) Score | Measured at 41 years. | Participants with a CAC Agatston score \>100, which is considered moderate or greater coronary plaque build-up, indicating an increased risk of heart disease. |
| Primary | Carotid-Femoral Pulse Wave Velocity (cfPWV) Measurement | Measured at 41 years. | Participants with a cfPWV \> 10 m/s. |
| Primary | Estimated Glomerular Filtration Rate (eGFR) Measurement | Measured at 41 years. | eGFR calculated using serum creatinine. |
| Secondary | Time to First Major Adverse Cardiovascular Event (MACE) | Up to 37 years. | Time from study baseline to the first instance of CVD death, MI, or stroke. Participants not experiencing MACE will be censored at their last event-free follow-up. |
| Secondary | Time to First Total Coronary Artery Disease (tCAD) Event | Up to 37 years. | Time from study baseline to the first instance of CAD death, MI, coronary revascularization, ischemic ECG at study visit, or study physician-diagnosed angina. Participants not experiencing tCAD will be censored at their last event-free follow-up. |
| Secondary | Time to First Hard Coronary Artery Disease (hCAD) Event | Up to 37 years. | Time from study baseline to the first instance of CAD death, MI, or coronary revascularization. Participants not experiencing hCAD will be censored at their last event-free follow-up. |
1 to 10 of 17Source ClinicalTrials.gov
See all 17 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07911033
GET https://conductscience.org/api/trials/v1/NCT07911033/registered