Trial · NCT07911059
Fluid Responsiveness in Laparoscopic Surgery: End-Expiratory Occlusion Test Versus Mini-Fluid Challenge
NCT07911059, Not yet recruiting, University Of Perugia
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Fluid Responsiveness in Laparoscopic Surgery: End-Expiratory Occlusion Test Versus Mini-Fluid Challenge. Trials, record NCT07911059. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07911059
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Fluid Responsiveness in Laparoscopic Surgery: End-Expiratory Occlusion Test Versus Mini-Fluid Challenge
- NCT number
- NCT07911059
- Status
- Not yet recruiting
- Enrollment
- 104 participants, estimated
- Lead sponsor
- University Of Perugia
- Conditions
- Fluid Responsiveness, Laparoscopic Surgery, Hemodynamic Monitoring
- First posted
- 2026-11-02
- Last updated
- 2026-11-02
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Difference in area under the ROC curve (AUC) between the mini-fluid challenge and the end-expiratory occlusion test for predicting fluid responsiveness | Perioperative/Periprocedural | Percent change in stroke volume index (ΔSVI%) after the mini-fluid challenge (100 ml lactated Ringer's over 1 minute) and after the end-expiratory occlusion test (30-second expiratory hold) is used as a continuous predictor. Fluid responsiveness is defined as an increase in stroke volume index of 10% or more after a fluid challenge of 4 ml/kg predicted body weight of lactated Ringer's over about 10 minutes. The AUCs of the two tests are compared as correlated ROC curves using the DeLong test. Stroke volume index is measured by uncalibrated pulse-contour analysis. |
| Secondary | Area under the ROC curve (AUC) of each test for predicting fluid responsiveness | Perioperative/Periprocedural | AUC with 95% confidence interval (DeLong) of the percent change in stroke volume index after the end-expiratory occlusion test (30 seconds) and after the mini-fluid challenge, and of baseline pulse pressure variation (PPV) and stroke volume variation (SVV), for predicting fluid responsiveness (increase in stroke volume index of 10% or more after a 4 ml/kg fluid challenge). |
| Secondary | Optimal cut-off, sensitivity, specificity, predictive values and likelihood ratios of each test | Perioperative/Periprocedural | For the end-expiratory occlusion test and the mini-fluid challenge: best cut-off of the percent change in stroke volume index by the Youden index, with sensitivity, specificity, positive and negative predictive values and positive and negative likelihood ratios, each with 95% confidence interval (Wilson method). |
| Secondary | Prevalence of fluid responsiveness in the study population | Perioperative/Periprocedural | Proportion of participants with an increase in stroke volume index of 10% or more after the 4 ml/kg fluid challenge of lactated Ringer's over about 10 minutes. |
| Secondary | Grey zone of each test and comparison of grey-zone widths | Perioperative/Periprocedural | Grey zone of the end-expiratory occlusion test and of the mini-fluid challenge, defined by a lower cut-off including 90% of non-responders and an upper cut-off predicting fluid responsiveness in 90% of cases. The intermediate range is considered inconclusive. The widths of the two grey zones are compared. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07911059
GET https://conductscience.org/api/trials/v1/NCT07911059/registered