Trial · NCT07911891
Oral Mecobalamin for TKI-Associated Hand-Foot Syndrome in Advanced Thyroid Cancer
NCT07911891, Phase 2, Completed, Li Zhihui
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Oral Mecobalamin for TKI-Associated Hand-Foot Syndrome in Advanced Thyroid Cancer. Trials, record NCT07911891. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07911891
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Oral Mecobalamin for TKI-Associated Hand-Foot Syndrome in Advanced Thyroid Cancer
- NCT number
- NCT07911891
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 100 participants, actual
- Lead sponsor
- Li Zhihui
- Conditions
- Thyroid Cancer, Hand-foot Syndrome
- Interventions
- Mecobalamin, Urea Ointment
- First posted
- 2026-11-03
- Last updated
- 2026-11-03
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Proportion of patients with HFS grade improvement ≥1 at week 8 | Week 8 | HFS grade is assessed by CTCAE v5.0 criteria. Improvement ≥1 grade means the HFS severity decreases by at least one level from baseline to week 8. |
| Secondary | Change in VAS pain score from baseline to week 8 | Week 8 | VAS pain score ranges from 0 (no pain) to 10 (worst pain). Change score = baseline score - week 8 score. |
| Secondary | Change in KPS performance status from baseline to week 8 | Week 8 | KPS score ranges from 0 (death) to 100 (normal activity). Change score = week 8 score - baseline score. |
| Secondary | Proportion of patients requiring TKI dose adjustment due to HFS | 8 weeks | Patients who require TKI dose reduction, interruption, or discontinuation due to HFS during the 8-week study period. |
| Secondary | Incidence of adverse events related to study medication | 8 weeks | All adverse events assessed by CTCAE v5.0 criteria, classified as related or unrelated to study medication. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers4
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07911891
GET https://conductscience.org/api/trials/v1/NCT07911891/registered