Trial · NCT07913464
PF-Organized Corticosteroid-Associated Heterogeneity in Sepsis
NCT07913464, Completed, Shanghai Zhongshan Hospital
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. PF-Organized Corticosteroid-Associated Heterogeneity in Sepsis. Trials, record NCT07913464. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07913464
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- PF-Organized Corticosteroid-Associated Heterogeneity in Sepsis
- NCT number
- NCT07913464
- Status
- Completed
- Enrollment
- 2,693 participants, actual
- Lead sponsor
- Shanghai Zhongshan Hospital
- Conditions
- Sepsis, Critical Illness
- Interventions
- Systemic Corticosteroids
- First posted
- 2026-11-03
- Last updated
- 2026-11-03
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | ICU Mortality | From ICU admission (cohort entry) until ICU discharge or death, whichever occurred first, during the index ICU stay. The maximum observed follow-up duration was 90 days. | Death during the index ICU stay, based on the ICU mortality variable recorded in each database. |
| Secondary | ICU Mortality by PaO2/FiO2 (P/F) Stratum | From ICU admission (cohort entry) until ICU discharge or death, whichever occurred first, during the index ICU stay. The maximum observed follow-up duration was 90 days. | ICU mortality evaluated separately in patients with baseline PaO₂/FiO₂ ≤200 mmHg and \>200 mmHg. |
| Secondary | Strategy-Level Association Between Early Corticosteroid Initiation and ICU Mortality | From cohort entry (ICU admission) until ICU discharge or death, whichever occurred first, during the index ICU stay. The treatment-strategy assignment window was the first 24 hours after cohort entry. The maximum observed follow-up duration was 90 days. | Comparison of ICU mortality between an early corticosteroid initiation strategy (within 24 hours after cohort entry) and a no-early-initiation strategy during the same 24-hour window, using the limited clone-censor-weighting framework. |
| Secondary | P/F-Stratified Associations Between Corticosteroid Exposure and ICU Mortality Across Cohorts | From ICU admission or cohort entry (time zero) until ICU discharge or death, whichever occurred first, during the index ICU stay. | Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for the association between systemic corticosteroid exposure and ICU mortality were compared across ICCA, MIMIC, and eICU cohorts within P/F ≤200 mmHg and P/F \>200 mmHg strata. Exposure windows followed source-specific definitions (0-72 hours in ICCA and within 24 hours in MIMIC and eICU). Broad and reconstructed external cohorts were evaluated separately. These exploratory comparisons did not constitute formal tests of cross-cohort replication, transportability, or causal effects. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07913464
GET https://conductscience.org/api/trials/v1/NCT07913464/registered