Intranasal Dexmedetomidine-esketamine Combination and Postoperative Cognitive Recovery in Older Patients
NCT07914803, Phase 4, Not yet recruiting, Peking University First Hospital
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Intranasal Dexmedetomidine-esketamine Combination and Postoperative Cognitive Recovery in Older Patients | ClinicalTrials.gov |
| NCT number | NCT07914803 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Phase 4 | ClinicalTrials.gov |
| Enrollment | 732 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Peking University First Hospital | ClinicalTrials.gov |
| Conditions | Older Patients, Noncardiac Surgery, Dexmedetomidine, Esketamine, Intranasal Administration, Perioperative Neurocognitive Disorders | ClinicalTrials.gov |
| Interventions | Intranasal dexmedetomidine-esketamine combination, Intranasal placebo (0.9% saline) | ClinicalTrials.gov |
| First posted | 2026-11-04 | ClinicalTrials.gov |
| Last updated | 2026-11-04 | ClinicalTrials.gov |
Registered outcomes 3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Incidence of delayed neurocognitive recovery (dNCR) on postoperative day 4. | Up to 4 days after surgery. | Cognitive function will be assessed with the Montreal Cognitive Assessment (MoCA; scores range from 0 to 30, with higher scores indicating better function) before surgery and on postoperative day 4 or at hospital discharge, whichever occurs first. Delayed neurocognitive recovery (dNCR) is defined as a decline from baseline of \>1 SD in MoCA score. | ClinicalTrials.gov |
| Secondary | Incidence of postoperative delirium within 3 days after surgery. | Up to 3 days after surgery. | Delirium will be assessed twice daily during the first 3 postoperative days using the 3-minute Diagnostic Interview for Confusion Assessment Method (3D-CAM) in non-intubated patients and the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) in intubated patients. | ClinicalTrials.gov |
| Secondary | Incidence of delayed neurocognitive recovery (dNCR) on postoperative day 30. | At 30 days after surgery. | Cognitive function will be assessed with the Telephone Montreal Cognitive Assessment (T-MoCA; scores range from 0 to 22, with higher scores indicating better function) before surgery and on postoperative day 30. Delayed neurocognitive recovery (dNCR) is defined as a decline from baseline of \>1 SD in T-MoCA score. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 42
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 16529526 | BACKGROUND | PubMed |
| 25700290 | BACKGROUND | PubMed |
| 26352694 | BACKGROUND | PubMed |
| 27344279 | BACKGROUND | PubMed |
| 27374833 | BACKGROUND | PubMed |
| 27542303 | BACKGROUND | PubMed |
| 27544872 | BACKGROUND | PubMed |
| 28263192 | BACKGROUND | PubMed |
| 28639236 | BACKGROUND | PubMed |
| 29661413 | BACKGROUND | PubMed |
| 29736744 | BACKGROUND | PubMed |
| 29801992 | BACKGROUND | PubMed |
| 29870457 | BACKGROUND | PubMed |
| 30032877 | BACKGROUND | PubMed |
| 30115258 | BACKGROUND | PubMed |
| 30336844 | BACKGROUND | PubMed |
| 31335550 | BACKGROUND | PubMed |
| 31765741 | BACKGROUND | PubMed |
| 32658246 | BACKGROUND | PubMed |
| 32826629 | BACKGROUND | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)