Multimodal MRI Assessment of Brain Fluid Circulation in Idiopathic Intracranial Hypertension
NCT07915453, Not yet recruiting, Beijing Tiantan Hospital
Trial 8
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Multimodal MRI Assessment of Brain Fluid Circulation in Idiopathic Intracranial Hypertension | ClinicalTrials.gov |
| NCT number | NCT07915453 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Enrollment | 105 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Beijing Tiantan Hospital | ClinicalTrials.gov |
| Conditions | Idiopathic Intracranial Hypertension | ClinicalTrials.gov |
| First posted | 2026-11-04 | ClinicalTrials.gov |
| Last updated | 2026-11-10 | ClinicalTrials.gov |
Registered outcomes 42
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Total Choroid Plexus Volume | Baseline | Total bilateral choroid plexus volume (mm³) measured using structural MRI. | ClinicalTrials.gov |
| Primary | Whole-Brain-Normalized Choroid Plexus Volume | Baseline | Choroid plexus volume normalized to whole-brain volume, expressed as a dimensionless ratio. | ClinicalTrials.gov |
| Primary | Peak Systolic Cerebrospinal Fluid Velocity in the Cerebral Aqueduct | Baseline | Peak systolic cerebrospinal fluid velocity (cm/s) in the cerebral aqueduct measured using phase-contrast MRI. | ClinicalTrials.gov |
| Primary | Peak Diastolic Cerebrospinal Fluid Velocity in the Cerebral Aqueduct | Baseline | Peak diastolic cerebrospinal fluid velocity (cm/s) in the cerebral aqueduct measured using phase-contrast MRI. | ClinicalTrials.gov |
| Primary | Mean Cerebrospinal Fluid Velocity in the Cerebral Aqueduct | Baseline | Mean cerebrospinal fluid velocity (cm/s) in the cerebral aqueduct measured using phase-contrast MRI. | ClinicalTrials.gov |
| Primary | Net Cerebrospinal Fluid Flow Rate Through the Cerebral Aqueduct | Baseline | Net cerebrospinal fluid flow rate (mL/min) through the cerebral aqueduct measured using cardiac-gated phase-contrast MRI. | ClinicalTrials.gov |
| Primary | Total Perivascular Space Volume Fraction | Baseline | Ratio of MRI-visible perivascular space volume to intracranial volume, derived from structural MRI. | ClinicalTrials.gov |
| Primary | Overall Diffusion Tensor Imaging Along the Perivascular Space Index | Baseline | Overall diffusion tensor imaging along the perivascular space (DTI-ALPS) index derived from diffusion MRI, expressed as a dimensionless ratio. | ClinicalTrials.gov |
| Primary | White Matter Free-Water Fraction | Baseline | Extracellular free-water fraction in cerebral white matter estimated using diffusion MRI. | ClinicalTrials.gov |
| Primary | Diffusion Tensor Imaging-Estimated Periventricular Diffusivity Index | Baseline | Periventricular diffusivity (PVeD) index estimated from the transverse tensor ratio (TTR) in periventricular white matter using diffusion tensor MRI. | ClinicalTrials.gov |
| Primary | Global Blood Oxygen Level-Dependent Signal-Cerebrospinal Fluid Coupling | Baseline | Pearson correlation coefficient (r) between the global gray-matter BOLD signal and the CSF inflow signal derived from resting-state functional MRI. | ClinicalTrials.gov |
| Primary | Whole-Brain Cerebral Blood Flow | Baseline | Mean whole-brain cerebral blood flow (mL/100 g/min) measured using arterial spin labeling MRI. | ClinicalTrials.gov |
| Primary | Gray Matter Cerebral Blood Flow | Baseline | Mean cerebral blood flow (mL/100 g/min) in gray matter measured using arterial spin labeling MRI. | ClinicalTrials.gov |
| Primary | White Matter Cerebral Blood Flow | Baseline | Mean cerebral blood flow (mL/100 g/min) in white matter measured using arterial spin labeling MRI. | ClinicalTrials.gov |
| Primary | White Matter Apparent Blood-Brain Barrier Water Exchange Rate | Baseline | Apparent blood-brain barrier water exchange rate (AXR\_BBB) in cerebral white matter estimated using vascular water exchange imaging (VEXI). | ClinicalTrials.gov |
| Primary | Deep Gray Matter Apparent Blood-Brain Barrier Water Exchange Rate | Baseline | Apparent blood-brain barrier water exchange rate (AXR\_BBB) in deep gray matter estimated using vascular water exchange imaging (VEXI). | ClinicalTrials.gov |
| Secondary | Cerebrospinal Fluid Opening Pressure | Baseline | Cerebrospinal fluid opening pressure (mmH₂O) measured during clinically indicated lumbar puncture in patients with IIH. | ClinicalTrials.gov |
| Secondary | Trans-Stenotic Venous Pressure Gradient | Baseline | Pressure gradient (mmHg) across venous sinus stenosis measured during clinically indicated venous manometry in patients with IIH. | ClinicalTrials.gov |
| Secondary | Visual Acuity | Baseline | Visual acuity recorded as a numerical measure during ophthalmological examination in patients with IIH. | ClinicalTrials.gov |
| Secondary | Visual Field Mean Deviation | Baseline | Visual field mean deviation (dB) measured using automated perimetry in patients with IIH. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Digit Span Test | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)