A MOST Framework Trial Evaluating the MOst effectiVe Exercise Types for Blood Pressure Control
NCT07915752, Not applicable, Not yet recruiting, Northwestern University
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | A MOST Framework Trial Evaluating the MOst effectiVe Exercise Types for Blood Pressure Control | ClinicalTrials.gov |
| NCT number | NCT07915752 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 264 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Northwestern University | ClinicalTrials.gov |
| Conditions | Hypertension | ClinicalTrials.gov |
| Interventions | Core intervention (Fitbit tracking and BP health education), Aerobic training (AT), Dynamic resistance training (DRT), Isometric resistance training (IRT) | ClinicalTrials.gov |
| First posted | 2026-11-04 | ClinicalTrials.gov |
| Last updated | 2026-11-06 | ClinicalTrials.gov |
Registered outcomes 20
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in resting systolic blood pressure | Baseline to 6 months | Resting brachial systolic blood pressure (mmHg) measured in person with a calibrated automated oscillometric device (SphygmoCor XCEL) after 10 minutes of rest. Three readings are taken 1 minute apart and averaged. Change from baseline will be compared between participants with each exercise component (AT, DRT, IRT) "on" versus "off." | ClinicalTrials.gov |
| Secondary | Change in resting systolic blood pressure at 3 and 12 months | Baseline, 3 months, and 12 months | Resting brachial systolic blood pressure (mmHg), measured as for the primary outcome, to assess early response (3 months) and maintenance of effect after the intervention ends (12 months). Change from baseline will be compared between participants with each component "on" versus "off." | ClinicalTrials.gov |
| Secondary | Change in resting diastolic blood pressure | Baseline, 3 months, 6 months, and 12 months | Resting brachial diastolic blood pressure (mmHg) measured with a calibrated automated oscillometric device (SphygmoCor XCEL); average of three readings taken 1 minute apart. | ClinicalTrials.gov |
| Secondary | Change in carotid-femoral pulse wave velocity | Baseline, 3 months, and 6 months | Central (aortic) arterial stiffness measured as carotid-femoral pulse wave velocity (m/s) by applanation tonometry (SphygmoCor). Only stable 10-second tracings with at least 80% of beats showing a detectable upstroke are included. | ClinicalTrials.gov |
| Secondary | Change in carotid-radial pulse wave velocity | Baseline, 3 months, and 6 months | Peripheral (muscular artery) stiffness measured as carotid-radial pulse wave velocity (m/s) by applanation tonometry (SphygmoCor). | ClinicalTrials.gov |
| Secondary | Change in total arterial stiffness | Baseline, 3 months, and 6 months | Total carotid pulse wave velocity (m/s) derived from carotid pressure and diameter measurements, used as the basis for separating structural and load-dependent stiffness. | ClinicalTrials.gov |
| Secondary | Change in structural arterial stiffness | Baseline, 3 months, and 6 months | Structural component of carotid pulse wave velocity (m/s), calculated with a participant-specific exponential model of arterial mechanics, with pressure and diameter adjusted to a standard reference pressure of 120/80 mmHg. | ClinicalTrials.gov |
| Secondary | Change in load-dependent arterial stiffness | Baseline, 3 months, and 6 months | Load-dependent component of carotid pulse wave velocity (m/s), calculated as total minus structural stiffness. Values are positive when blood pressure is above 120/80 mmHg and negative when below. | ClinicalTrials.gov |
| Secondary | Change in brachial artery flow-mediated dilation | Baseline, 3 months, and 6 months | Conduit artery endothelial function measured as percent flow-mediated dilation (%) by B-mode ultrasound after 5 minutes of lower-arm cuff occlusion at 250 mmHg, following a standardized brachial artery reactivity protocol. Peak diameter is recorded 60 and 90 seconds after cuff release. | ClinicalTrials.gov |
| Secondary | Change in common carotid artery distensibility | Baseline, 3 months, and 6 months | Change in common carotid artery diameter between systole and diastole (mm), measured in triplicate across 3 consecutive cardiac cycles by carotid ultrasound and read by a blinded central core lab. | ClinicalTrials.gov |
| Other | Change in central blood pressure and aortic augmentation index | Baseline, 3 months, and 6 months | Central aortic systolic and diastolic blood pressure (mmHg) and aortic augmentation index normalized to a heart rate of 75 bpm (%), derived from radial artery waveforms using a validated generalized transfer function (SphygmoCor). | ClinicalTrials.gov |
| Other | Change in carotid artery wall echogenicity and texture | Baseline, 3 months, and 6 months | Grayscale median, entropy, gray-level difference statistics-contrast, and spatial gray level dependence matrices measured from carotid ultrasound images at end-diastole, reflecting early microstructural remodeling of the arterial wall. | ClinicalTrials.gov |
| Other | Change in moderate-to-vigorous physical activity | Baseline, 3 months, 6 months, and 12 months | Minutes per week of moderate-to-vigorous physical activity measured by hip-worn ActiGraph wGT3X-BT accelerometer over 7 days (valid wear: at least 10 waking hours per day on at least 5 days; at least 2,020 counts/min). | ClinicalTrials.gov |
| Other | Change in 6-minute walk distance | Baseline, 3 months, 6 months, and 12 months | Submaximal aerobic capacity measured as distance walked (meters) in 6 minutes with standardized feedback. | ClinicalTrials.gov |
| Other | Change in 1-repetition maximum strength | Baseline, 3 months, 6 months, and 12 months | Maximum weight (kg) a participant can lift once with proper form, used to assess muscle strength. | ClinicalTrials.gov |
| Other | Muscle-strengthening exercise participation | Baseline, 3 months, 6 months, and 12 months | Muscle-strengthening exercise participation in a usual week, self-reported using the 9-item Muscle-Strengthening Exercise Questionnaire (MSEQ). Outcomes are frequency (days per week; range 0-7), duration (minutes per usual session, reported in categories from 0 to 60 or more), and intensity, rated on the OMNI Perceived Exertion Scale for Resistance Exercise (minimum 0 "extremely easy," maximum 10 "extremely hard"; higher scores mean greater exertion). For frequency and duration, higher values indicate more muscle-strengthening exercise. | ClinicalTrials.gov |
| Other | Change in body weight | Baseline, 3 months, 6 months, and 12 months | Body weight (kg) measured using standard protocols, explored as a mediator of blood pressure response. | ClinicalTrials.gov |
| Other | Change in diet quality | Baseline, 3 months, 6 months, and 12 months | Healthy Eating Index-2020 (HEI-2020) total score computed from three web-based Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24) recalls (two weekdays and one weekend day). Minimum score 0, maximum score 100; higher scores mean a better outcome (better diet quality). | ClinicalTrials.gov |
| Other | Exercise session adherence | Baseline to 6 months | Percentage of prescribed exercise sessions completed and percentage of total prescribed weekly dose time completed, tracked through Fitbit data and the coaching portal. | ClinicalTrials.gov |
| Other | Intervention acceptability | Monthly from month 1 to month 6 | Physical Activity Acceptance Questionnaire (PAAQ) total score, administered monthly (6 total). The PAAQ consists of 10 items rated from 1 ("never true") to 7 ("always true"). Total scores range from a minimum of 10 to a maximum of 70; higher scores mean a better outcome (greater acceptance). | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)