Comparison of Intensive and Conservative NOL®-Guided Analgesia Strategies During Opioid-free Anesthesia
NCT07917299, Not applicable, Not yet recruiting, Prof Urs Zingg
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Comparison of Intensive and Conservative NOL®-Guided Analgesia Strategies During Opioid-free Anesthesia | ClinicalTrials.gov |
| NCT number | NCT07917299 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 400 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Prof Urs Zingg | ClinicalTrials.gov |
| Conditions | Anesthesia, Bariatric Surgery (Gastric Bypass) | ClinicalTrials.gov |
| Interventions | Study Intervention, Control Intervention | ClinicalTrials.gov |
| First posted | 2026-11-04 | ClinicalTrials.gov |
| Last updated | 2026-11-04 | ClinicalTrials.gov |
Registered outcomes 11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Postoperative pain intensity Measured by the numeric rating scale (NRS) in the Post-anesthesia care unit (PACU) | At the Date of Surgery + 1 day after at Post-anesthesia care unit (PACU): two assessments within 2 consequent days | To evaluate whether an intensive NOL®-guided analgesia strategy reduces postoperative pain intensity in the post-anesthesia care unit (PACU) compared to a conservative NOL®-guided analgesia strategy in patients undergoing bariatric surgery under OFA. | ClinicalTrials.gov |
| Primary | Postoperative pain intensity Measured by the Behavioral Pain Scale (BPS) in the Post-anesthesia care unit (PACU) | At the Date of Surgery + 1 day after at Post-anesthesia care unit (PACU): two assessments within 2 consequent days | To evaluate whether an intensive NOL®-guided analgesia strategy reduces postoperative pain intensity in the post-anesthesia care unit (PACU) compared to a conservative NOL®-guided analgesia strategy in patients undergoing bariatric surgery under OFA. | ClinicalTrials.gov |
| Secondary | Difference between postoperative pain intensity measurement using the Behavioral Pain Scale (BPS) (outcome 1) and numeric rating scale (NRS) (outcome 2) in the Post-anesthesia care unit (PACU) | At the Date of Surgery + 1 day after at Post-anesthesia care unit (PACU): two assessments within 2 consequent days | Difference between the outcome 1 and outcome 2 | ClinicalTrials.gov |
| Secondary | Total opioid consumption in the Post-anesthesia care unit (PACU) | At the Date of Surgery + 1 day after at Post-anesthesia care unit (PACU): two assessments within 2 consequent days | Morphin (mg), Oxynorm (mg), Oxycodon/Naloxon (mg) | ClinicalTrials.gov |
| Secondary | - Total non-opioid analgesic consumption in the Post-anesthesia care unit (PACU) | At the Date of Surgery + 1 day after at Post-anesthesia care unit (PACU): two assessments within 2 consequent days | Paracetamol (mg), Metamizol (mg), Ketamin (mg) | ClinicalTrials.gov |
| Secondary | - Total non-opioid analgesic consumption in the Post-anesthesia care unit (PACU) | At the Date of Surgery + 1 day after at Post-anesthesia care unit (PACU): two assessments within 2 consequent days | Lidocain-P (mg/kgLBW/h) | ClinicalTrials.gov |
| Secondary | - Total non-opioid analgesic consumption in the Post-anesthesia care unit (PACU) | At the Date of Surgery + 1 day after at Post-anesthesia care unit (PACU): two assessments within 2 consequent days | Ketamin-Perfusor (mg/h) | ClinicalTrials.gov |
| Secondary | - Incidence of Postoperative nausea and vomiting (PONV) | At the Date of Surgery + 1 day after at Post-anesthesia care unit (PACU): two assessments within 2 consequent days | The proportion of patients who experience at least one episode of postoperative nausea, retching, or vomiting, or who require the administration of any antiemetic rescue medication (such as Ondansetron, Metoclopramide, Domperidone, or Itinerol). | ClinicalTrials.gov |
| Secondary | - Richmond Agitation-Sedation Scale (RASS) scores during Post-anesthesia care unit (PACU) stay | At the Date of Surgery + 1 day after at Post-anesthesia care unit (PACU): two assessments within 2 consequent days | ClinicalTrials.gov | |
| Secondary | - Quality of Recovery-15 (QoR-15) score on postoperative day 1 | At the Date of Surgery + 1 day after at Post-anesthesia care unit (PACU): two assessments within 2 consequent days | ClinicalTrials.gov | |
| Other | Safety endpoints | At the Date of Surgery + 1 day after at Post-anesthesia care unit (PACU): two assessments within 2 consequent days | \- measures of intraoperative hemodynamic stability, including the incidence of hypotension, bradycardia, hypertension, tachycardia, and vasoactive medication use - occurrence of AEs and SAEs during the study period | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)