A Prospective, Open-label, Randomized, Multicenter Phase-III Trial to Evaluate the Efficacy of Pirtobrutinib and Epcoritamab Compared With R-(Mini)-CHOP for Treatment of Patients With DLBCL-type Richter Transformation
NCT07917780, Phase 2, Recruiting, German CLL Study Group
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | A Prospective, Open-label, Randomized, Multicenter Phase-III Trial to Evaluate the Efficacy of Pirtobrutinib and Epcoritamab Compared With R-(Mini)-CHOP for Treatment of Patients With DLBCL-type Richter Transformation | ClinicalTrials.gov |
| NCT number | NCT07917780 | ClinicalTrials.gov |
| Status | Recruiting | ClinicalTrials.gov |
| Phases | Phase 2 | ClinicalTrials.gov |
| Enrollment | 116 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | German CLL Study Group | ClinicalTrials.gov |
| Conditions | Richter Transformation | ClinicalTrials.gov |
| Interventions | Epcoritamab, Pirtobrutinib, Cyclophosphamide, Doxorubicin, Vincristine, Rituximab | ClinicalTrials.gov |
| First posted | 2026-11-05 | ClinicalTrials.gov |
| Last updated | 2026-11-05 | ClinicalTrials.gov |
Registered outcomes 10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | PFS | approx. 40 months after first subject in | Investigator-assessed progression-free survival (PFS) according to Lugano criteria | ClinicalTrials.gov |
| Secondary | ORR | approx. 40 months after first subject in | Overall response rate (ORR) at the end of (combination) treatment according to Lugano criteria | ClinicalTrials.gov |
| Secondary | CRR | approx. 40 months after first subject in | Complete response rate (CRR) at the end of (combination) treatment according to Lugano criteria | ClinicalTrials.gov |
| Secondary | Best response according to Lugano criteria | approx. 40 months after first subject in | Best response according to Lugano criteria | ClinicalTrials.gov |
| Secondary | Undetectable minimal residual disease (uMRD) | approx. 40 months after first subject in | Undetectable minimal residual disease (uMRD) rates in peripheral blood at the end of (combination) treatment | ClinicalTrials.gov |
| Secondary | DOR | approx. 40 months after first subject in | Duration of response (DOR) according to Lugano criteria | ClinicalTrials.gov |
| Secondary | Overall survival (OS) | approx. 40 months after first subject in | Overall survival (OS) | ClinicalTrials.gov |
| Secondary | TTNT | approx. 40 months after first subject in | Time to next treatment (TTNT) | ClinicalTrials.gov |
| Secondary | TFS | approx. 40 months after first subject in | Treatment-free survival (TFS) | ClinicalTrials.gov |
| Secondary | SCT | approx. 40 months after first subject in | Proportion of patients receiving allogeneic stem cell transplantation (SCT) for consolidation | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)