Effects of Intravenous Methylprednisolone After Mandibular Third Molar Surgery
NCT07918092, Not applicable, Completed, Abant Izzet Baysal University
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Effects of Intravenous Methylprednisolone After Mandibular Third Molar Surgery | ClinicalTrials.gov |
| NCT number | NCT07918092 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 30 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Abant Izzet Baysal University | ClinicalTrials.gov |
| Conditions | Impacted Mandibular Third Molars | ClinicalTrials.gov |
| Interventions | Methylprednisolone Sodium Succinate (40 mg IV), Amoxicillin/Clavulanic Acid (Postoperative 7-Day Regimen), Amoxicillin/Clavulanic Acid (Single-Dose Preoperative Prophylaxis) | ClinicalTrials.gov |
| First posted | 2026-11-05 | ClinicalTrials.gov |
| Last updated | 2026-11-05 | ClinicalTrials.gov |
Registered outcomes 5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in Serum C-Reactive Protein (CRP) Levels | Preoperative baseline and postoperative days 1, 3, and 7 after each surgery | Serum C-reactive protein (CRP) levels were measured to evaluate the systemic inflammatory response following surgical extraction of impacted mandibular third molars. Changes in CRP levels from the preoperative baseline were assessed and compared between the different medication protocols. CRP concentrations were recorded in mg/L, with higher values indicating greater systemic inflammation | ClinicalTrials.gov |
| Primary | Postoperative Pain Intensity (VAS Score) | Postoperative days 1 through 7 after each surgical procedure | Postoperative pain intensity was evaluated using a patient-reported visual analog scale (VAS), ranging from 0 (no pain) to 10 (worst imaginable pain). Pain scores were recorded following each surgical procedure and compared between the different medication protocols. Higher VAS scores indicated greater pain intensity. | ClinicalTrials.gov |
| Secondary | Change in Facial Swelling Assessed by the Modified Gabka and Matsumura Method | Preoperative baseline and postoperative days 1, 3, and 7 after each surgery. | Postoperative facial swelling was assessed using the modified Gabka and Matsumura method based on three standardized linear facial measurements: tragus to oral commissure (AC), tragus to pogonion (AD), and lateral canthus to mandibular angle (BE). Measurements were obtained preoperatively and on postoperative days 1, 3, and 7. Changes from baseline measurements were evaluated to assess postoperative facial swelling and compare treatment protocols. | ClinicalTrials.gov |
| Secondary | Change in Erythrocyte Sedimentation Rate (ESR) | Preoperative baseline and postoperative days 1, 3, and 7 after each surgery. | Erythrocyte sedimentation rate (ESR) was measured to evaluate the systemic inflammatory response following surgery. Changes from preoperative baseline values were assessed and compared between treatment protocols. | ClinicalTrials.gov |
| Secondary | Change in Serum Procalcitonin Levels | Preoperative baseline and postoperative days 1, 3, and 7 after each surgery | Serum procalcitonin levels were measured to evaluate the systemic inflammatory response following surgical extraction of impacted mandibular third molars. Blood samples were collected before surgery and on postoperative days 1, 3, and 7 following each surgical procedure. Changes in procalcitonin concentrations from preoperative baseline values were evaluated and compared between treatment protocols. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 4925048 | BACKGROUND | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)