LEANDIP: Lean Diabetes in Asian Indians
NCT07918170, Not yet recruiting, Diabetes Foundation, India
Trial 9
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | LEANDIP: Lean Diabetes in Asian Indians | ClinicalTrials.gov |
| NCT number | NCT07918170 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Enrollment | 151 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Diabetes Foundation, India | ClinicalTrials.gov |
| Conditions | Lean Diabetes Mellitus, Type 2 Diabetes, β-cell Dysfunction, Metabolic Abnormalities, Diabetes in Asian Indian | ClinicalTrials.gov |
| Interventions | The study does not involve any therapeutic or lifestyle intervention. Participants will undergo clinical evaluation, biochemical testing, genomic and metabolomic analysis, BCA, pancreatic imaging. | ClinicalTrials.gov |
| First posted | 2026-11-05 | ClinicalTrials.gov |
| Last updated | 2026-11-05 | ClinicalTrials.gov |
Registered outcomes 3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Primary Outcome: Genomic and Metabolomic Characterization of Lean Diabetes | 30 months | Identification of an integrated biological phenotype distinguishing lean type 2 diabetes from healthy lean individuals and non-lean T2D (Genomic signatures, Metabolomic signatures, β-cell function, body fat compartments) | ClinicalTrials.gov |
| Secondary | Secondary Outcome: Pancreatic and Body Composition Phenotype | 30 months | Quantification of pancreatic fat fraction, pancreatic volume, and hepatic fat content using CSE-MRI (PDFF) protocol. Assessment of body composition parameters including percent body fat, fat mass, truncal body fat, fat-free mass, and abdominal fat depot distribution, Assessment of pancreatic β-cell function and insulin secretory reserve using fasting and stimulated insulin and C-peptide concentrations obtained during a standardized mixed meal tolerance test (MMTT), together with HOMA-IR, HOMA-β, Δ insulin,Δ C-peptide and stimulated-to-fasting response ratios. | ClinicalTrials.gov |
| Other | Tertiary Outcome: Clinical Progression and Metabolic Characteristics at 1-Year Follow-up among individuals with lean diabetes | 30 months | Longitudinal assessment of glycemic control (HbA1c, fasting and postprandial glucose), anthropometric changes (BMI, waistcircumference, body composition), and progression of diabetes-related complications (retinopathy, neuropathy, nephropathy,cardiovascular and cerebrovascular disease) Evaluation of treatment requirements and therapeutic response, including insulin dependency and oral antidiabetic medication needs Comparison of nutritional status, lifestyle factors (diet, physical activity), psychological profile (mental health screening), and complicationburden between baseline and 1-year follow-up. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)