Affective Cognitive Training in Mood Disorders and High-risk Relatives
NCT07920302, Not applicable, Recruiting, Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Affective Cognitive Training in Mood Disorders and High-risk Relatives | ClinicalTrials.gov |
| NCT number | NCT07920302 | ClinicalTrials.gov |
| Status | Recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 100 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital | ClinicalTrials.gov |
| Conditions | Major Depressive Disorder (MDD), Bipolar Disorder (BD) | ClinicalTrials.gov |
| Interventions | Targeted affective cognitive training | ClinicalTrials.gov |
| First posted | 2026-11-05 | ClinicalTrials.gov |
| Last updated | 2026-11-05 | ClinicalTrials.gov |
Registered outcomes 32
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Affective cognitive composite measure | Baseline and week 7 (treatment completion) | A composite score of affective cognition based on the following tests: the Social Scenarios Task (down-regulation of negative emotion), the VERA task (down-regulation of negative emotion) and the Facial Expression Recognition Task (discrimination accuracy and speed of facial expression recognition). Higher scores reflect better performance. | ClinicalTrials.gov |
| Secondary | Dorsal prefrontal cortex activity during emotion regulation | Baseline and week 7 (treatment completion) | Functional magnetic resonance imaging (fMRI) measure of brain activity in a dorsal prefrontal volume of interest during an emotion regulation task using IAPS pictures (down-regulation versus react to negative pictures). | ClinicalTrials.gov |
| Secondary | Difficulties in Emotion Regulation Scale (DERS) | Baseline, week 7 (treatment completion), 6 months (follow-up) | Questionnaire assessing self-rated emotion regulation difficulties. Lower scores reflect better outcome. | ClinicalTrials.gov |
| Other | VERA | Baseline and week 7 | Virtual Reality task assessing emotion regulation. Score range 1-5 (lower scores reflect better outcome). | ClinicalTrials.gov |
| Other | Social Scenarios Task | Baseline and week 7 (treatment completion) | Computerized neuropsychological test assessing emotional reactivity and emotion regulation in positive and negative situations. Outcomes include emotion reactivity (score range 0-100, lower scores reflect better outcome) and dampening (score range 0-100, lower scores reflect better outcome). | ClinicalTrials.gov |
| Other | Facial Expression Recognition Task (FERT) | Baseline and week 7 (treatment completion) | Computerized neuropsychological test assessing emotion recognition. Outcomes include reaction time (no score range, lower scores reflect better performance) and hit rate (score range 0-1, higher scores reflect better performance). | ClinicalTrials.gov |
| Other | Valence bias task | Baseline and week 7 (treatment completion) | Computerized task assessing valence judgements of emotionally ambiguous and clearly valenced stimuli, including faces and scenes | ClinicalTrials.gov |
| Other | Hamilton Depression Rating Scale (HDRS-17) | Baseline and week 7 (treatment completion) | Rating inventory assessing depressive symptoms. Score range 0-52. Lower scores reflect better outcome. | ClinicalTrials.gov |
| Other | Young Mania Rating Scale (YMRS) | Baseline and week 7 (treatment completion) | Rating inventory assessing (hypo)manic symptoms. Score range 0-60. Lower scores reflect better outcome. | ClinicalTrials.gov |
| Other | Functional Assessment Short Test (FAST) | Baseline and week 7 (treatment completion) | Interview-based assessment of functional capacity. Score range 0-72. Lower scores reflect better outcome. | ClinicalTrials.gov |
| Other | Neural activity during an implicit emotional face-processing task | Baseline and week 7 (treatment completion) | Functional magnetic resonance imaging (fMRI) measure of brain activity during fearful and happy face processing | ClinicalTrials.gov |
| Other | Neural activity during a verbal n-back task | Baseline and week 7 (treatment completion) | Functional magnetic resonance imaging (fMRI) measure of brain activity during a working memory task | ClinicalTrials.gov |
| Other | Neural activity during resting state | Baseline and week 7 (treatment completion) | Functional magnetic resonance imaging (fMRI) measure of brain activity during resting state | ClinicalTrials.gov |
| Other | Changes in brain structure | Baseline and week 7 (treatment completion) | Structural magnetic resonance imaging (sMRI) measure of brain morphology, including regional brain volumes and cortical thickness | ClinicalTrials.gov |
| Other | Wechsler Adult Intelligence Scale (WAIS)-III Letter-Number Sequencing | Baseline and week 7 (treatment completion) | Neuropsychological test assessing working memory. Score range 0-21. Higher scores reflect better performance. | ClinicalTrials.gov |
| Other | Trail Making Test A | Baseline and week 7 (treatment completion) | Neuropsychological test assessing attention and processing speed. Scored as time to complete. Lower scores reflect better performance. | ClinicalTrials.gov |
| Other | Trail Making Test B | Baseline and week 7 (treatment completion) | Neuropsychological test assessing executive function. Scored as time to complete. Lower scores reflect better performance. | ClinicalTrials.gov |
| Other | Verbal fluency with letters "S" and "D" | Baseline and week 7 (treatment completion) | Neuropsychological test assessing executive functions. No score range. Higher scores reflect better performance. | ClinicalTrials.gov |
| Other | Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Digit Span Test | Baseline and week 7 (treatment completion) | Neuropsychological test assessing attention. Score range 0-16. Higher scores reflect better performance. | ClinicalTrials.gov |
| Other | Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Coding | Baseline and week 7 (treatment completion) | Neuropsychological test assessing psychomotor speed. Score range 0-89. Higher scores reflect better performance. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 9
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| 1-Back Task | Other outcome | ConductCognition |
| 2-Back Task | Other outcome | ConductCognition |
| Digit Span Test | Other outcome | ConductCognition |
| Emotion Regulation Task | Secondary outcome | ConductCognition |
| Letter-Number Sequencing Task | Other outcome | ConductCognition |
| Trail Making Test A | Other outcome | ConductCognition |
| Trail Making Test B | Other outcome | ConductCognition |
| Verbal Fluency | Other outcome | ConductCognition |
| Verbal Learning | Other outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)