"Comparison of Oxygen Reserve Index (ORI), End-Tidal Oxygen, and Time-Based Preoxygenation Targets With Arterial Blood Gas During Preoxygenation
NCT07921849, Not yet recruiting, Kocaeli City Hospital
Trial 8
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | "Comparison of Oxygen Reserve Index (ORI), End-Tidal Oxygen, and Time-Based Preoxygenation Targets With Arterial Blood Gas During Preoxygenation | ClinicalTrials.gov |
| NCT number | NCT07921849 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Enrollment | 30 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Kocaeli City Hospital | ClinicalTrials.gov |
| Conditions | Preoxygenation Adequacy Assessed by Oxygen Reserve Index, End-tidal Oxygen and Arterial Blood Gas | ClinicalTrials.gov |
| First posted | 2026-11-06 | ClinicalTrials.gov |
| Last updated | 2026-11-06 | ClinicalTrials.gov |
Registered outcomes 5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Arterial Partial Pressure of Oxygen (PaO2) at Three Preoxygenation Targets | During preoxygenation before induction of anesthesia (from baseline up to 5 minutes) | PaO2 (mmHg) measured by arterial blood gas analysis from the existing arterial line at three preoxygenation targets in the same patient: when the Oxygen Reserve Index (ORI) reaches 0.45 or higher (T1), when end-tidal oxygen (EtO2) reaches 90% or higher (T2), and at the 3rd minute of preoxygenation (T3). PaO2 values at these targets will be compared within patients. If time points coincide, a single sample will represent all coinciding targets. | ClinicalTrials.gov |
| Secondary | Time to Reach Each Preoxygenation Target | During preoxygenation (up to 5 minutes) | Time (seconds) from the start of preoxygenation (T0) to reach ORI of 0.45 or higher and EtO2 of 90% or higher. | ClinicalTrials.gov |
| Secondary | Proportion of Patients Reaching Each Preoxygenation Target | During preoxygenation (up to 5 minutes) | Number and percentage of patients who reach ORI of 0.45 or higher and EtO2 of 90% or higher within 5 minutes of preoxygenation. | ClinicalTrials.gov |
| Secondary | Correlation Between ORI, EtO2 and PaO2 | During preoxygenation (up to 5 minutes) | Correlation coefficients between ORI and PaO2, EtO2 and PaO2, and ORI and EtO2, using all paired measurements at T0, T1, T2 and T3, accounting for repeated measurements within patients. | ClinicalTrials.gov |
| Secondary | Diagnostic Performance of ORI for PaO2 of 150 mmHg and 200 mmHg or Higher | During preoxygenation (up to 5 minutes) | Area under the receiver operating characteristic curve (AUC) with 95% confidence interval for ORI in identifying PaO2 of 150 mmHg or higher and 200 mmHg or higher. Optimal cut-off values, sensitivity and specificity will be calculated using the Youden index, as exploratory analyses. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 13
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 21447489 | BACKGROUND | PubMed |
| 30138170 | BACKGROUND | PubMed |
| 31227971 | BACKGROUND | PubMed |
| 33538433 | BACKGROUND | PubMed |
| 33728189 | BACKGROUND | PubMed |
| 36510457 | BACKGROUND | PubMed |
| 36517052 | BACKGROUND | PubMed |
| 37161369 | BACKGROUND | PubMed |
| 37863861 | BACKGROUND | PubMed |
| 39248302 | BACKGROUND | PubMed |
| 40522542 | BACKGROUND | PubMed |
| 41203471 | BACKGROUND | PubMed |
| 41227042 | BACKGROUND | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)