Compulsive Eating and Brain's Reward System in Different Pathologies
NCT07923513, Not applicable, Not yet recruiting, University Hospital, Clermont-Ferrand
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Compulsive Eating and Brain's Reward System in Different Pathologies | ClinicalTrials.gov |
| NCT number | NCT07923513 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 150 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | University Hospital, Clermont-Ferrand | ClinicalTrials.gov |
| Conditions | PARKINSON DISEASE (Disorder), Bipolar 1 Disorder, Obesity (BMI>30) | ClinicalTrials.gov |
| Interventions | MRI/ MRS (Magnetic Resonance Imaging /Magnetic Resonance Spectroscopy) | ClinicalTrials.gov |
| First posted | 2026-11-06 | ClinicalTrials.gov |
| Last updated | 2026-11-06 | ClinicalTrials.gov |
Registered outcomes 24
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Assessment of resting state seed-based functional connectivity from the limbic striatum (seed: ventral striatum) by MRI. | At visit 2, between 1 and 12 weeks after patient enrollment | MRI is a 3-Tesla MAGNETOM Vida scanner (Siemens, Erlangen, Germany) with a 64 channel head coil. The subjects were asked to hold still, with their eyes open and not to think of anything particular. Foam padding was employed to reduce head movement and earplugs were used to reduce scanner noise. The high resolution anatomical images were obtained through a T1-weighted magnetization-prepared rapid gradient echo (MPRAGE) sequence with the following parameters: repetition time (TR): 2300 ms, echo time (TE): 3.08 ms, inversion time (IT): 900 ms, flip angle (FA): 9°, matrix: 288 x 288, 176 slices, slice thickness: 1mm. Resting-state functional MRI images were obtained using an EPI sequence with the following parameters: TR: 3000ms, TE: 30ms, FA: 81°, field of view (FOV): 192 mm, 55 slices, slice thickness: 3.3 mm, gap between slices: 3.3 mm, pixel bandwidth: 2441 Hz/Pixel, number of time points: 180, acquisition duration: 9 minutes). | ClinicalTrials.gov |
| Secondary | Demographical data | at visit 1, selection visit - Day 0 | sex | ClinicalTrials.gov |
| Secondary | Demographical data | at visit 1, selection visit - Day 0 | Age (year) | ClinicalTrials.gov |
| Secondary | Demographical data | at visit 1, selection visit - Day 0 | weight (kg) | ClinicalTrials.gov |
| Secondary | Demographical data | at visit 1, selection visit - Day 0 | size (m) | ClinicalTrials.gov |
| Secondary | Parkinson Disease severity | at visit 1, selection visit - Day 0 | Assessment of parkinson desease with the MDS-UPDRS (Movement Disorders Society - Unified Parkinson's Disease Rating Scale ) scale, completed by the investigator. | ClinicalTrials.gov |
| Secondary | Bipolar Disease severity | at visit 1, selection visit - Day 0 | Assessment of bipolar desease with MADRS (Montgomery-Asberg Depression Rating Scale) and YMRS (Young Mania Rating Scale) scale, completed by the investigator. | ClinicalTrials.gov |
| Secondary | Obesity disease severity | at visit 1, selection visit - Day 0 | Obesity classification according to Health French Agency (Haute Autorité de Santé) 2022, completed by the investigator. | ClinicalTrials.gov |
| Secondary | Impulsive trait of Personality according the Barratt impulsiveness scale (BIS-11) | at visit 1, selection visit - Day 0 | This self questionnaire is completed by the patient during the selection visit | ClinicalTrials.gov |
| Secondary | Eating behavior disorder severity | at visit 1, selection visit - Day 0 | Self reported eating behavior disorder using 3 questionnaires (QEWP5 (Questionnaire on Eating and Weight Patterns5), DEBQ (Dutch Eating Behaviour Questionnaire) and food craving questionnaire)) | ClinicalTrials.gov |
| Secondary | Presence of Anxiety and/or depression according the Beck depression and anxiety scale | at visit 1, selection visit - Day 0 | These self questionnaires is completed by the patient during the selection visit | ClinicalTrials.gov |
| Secondary | Presence of restless legs syndrome according the International Restless Legs Syndrome (Rating Scale) | at visit 1, selection visit - Day 0 | This questionnaire is completed by the investigator during the selection visit | ClinicalTrials.gov |
| Secondary | Intensity and Pain caracteristics | at visit 1, selection visit - Day 0 | Patients will evaluate their pain using 2 self questionnaires (3-PDQ, BPI (Brief Pain Inventory)) | ClinicalTrials.gov |
| Secondary | Impulsive compulsive behaviors rating scale for PD (QUIP-RS) | at visit 2, between 1 and 12 weeks after selection visit | The QUIP-RS is a brief 28-item patient-reported or clinician-rated scale developped for measure of severity of ICDs. Each item is rated on a 5-point Likert scale assessing frequency of symptoms with a range of scores from 0 (never) to 4 (very often). | ClinicalTrials.gov |
| Secondary | Spontaneous food intake | at visit 2, between 1 and 12 weeks after selection visit | Patients will report thier spontaneous food intake for 3 days using a dietary data collected. Patient nutritional intakes will be analysed using Nutrilog software | ClinicalTrials.gov |
| Secondary | Motor impulsivity (Go/No Go task) | at visit 2, between 1 and 12 weeks after selection visit | Motor impulsivity will be assessed with the Go/No-go task. It is a simple experimental paradigm that requires participants to respond as quickly as possible (Go) to a particular class of stimuli, for example by pressing a key on a keyboard, and not to respond to other classes of stimuli (No Go). The key behaviour measured with this experiment is the participants' ability to withhold a response on No-go trials. | ClinicalTrials.gov |
| Secondary | Motor inhibition (Stop Signal Task (SST)) | at visit 2, between 1 and 12 weeks after selection visit | The Stop Signal Task (SST) is a test that measures motor inhibition. The participant must respond quickly to Go stimuli but interrupt their response when a stop signal appears. The key index, the Stop Signal Reaction Time (SSRT), reflects the time required to stop an ongoing action. This test will be performed by neuropsychologist. | ClinicalTrials.gov |
| Secondary | Iowa Gambling Task (IGT) | at visit 2, between 1 and 12 weeks after selection visit. | IGT assesses risk-based learning by relying on a system of rewards and punishments within a simulated context of uncertainty, representing a real-life decision-making situation. Participants choose cards from four decks, each associated with varying amounts of monetary gains and losses. Over time, advantageous decks yield higher net rewards, while disadvantageous decks lead to net losses. Performance on the task reflects an individual's capacity to balance immediate rewards against long-term outcomes, thereby providing insight into adaptive decision-making and risk evaluation processes. This test will be performed by neuropsychologist. | ClinicalTrials.gov |
| Secondary | Cognitive impulsivity (Stroop) | at visit 2, between 1 and 12 weeks after selection visit | The Stroop Test is a cognitive task designed to evaluate attentional control and the ability to inhibit automatic responses when faced with conflicting information. Participants are asked to name the color of the ink in which words are printed, even when the word itself refers to a different color (e.g., GREEN printed in red ink). This requires suppressing the automatic tendency to read the word and instead focusing on the ink color. The difference in performance between congruent and incongruent conditions, known as the Stroop interference effect, is a key indicator of cognitive inhibition and executive control. This test will be performed by neuropsychologist. | ClinicalTrials.gov |
| Secondary | Time perception (delay discounting reward task) | at visit 2, between 1 and 12 weeks after selection visit | Participants make choices between two alternatives: a larger reward available after a delay (across seven delay intervals) and a smaller reward available immediately. The value of the immediate reward is systematically adjusted, either increasing or decreasing, in separate blocks. The task assesses preferences for immediate versus delayed gratification using two reward types: money and food. This test will be performed by neuropsychologist. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 6
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Balloon Risk | Secondary outcome | ConductCognition |
| Delay Discounting | Secondary outcome | ConductCognition |
| Go/No-Go Task | Secondary outcome | ConductCognition |
| Iowa Gambling Lite | Secondary outcome | ConductCognition |
| Stop-Signal Task | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)