Supplemental Oxygen for Sleep-Disordered Breathing in Adults With Chronic Opioid Use.
NCT07923760, Phase 2, Not yet recruiting, University of California, San Diego
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Supplemental Oxygen for Sleep-Disordered Breathing in Adults With Chronic Opioid Use. | ClinicalTrials.gov |
| NCT number | NCT07923760 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Phase 2 | ClinicalTrials.gov |
| Enrollment | 62 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | University of California, San Diego | ClinicalTrials.gov |
| Conditions | Sleep-disordered Breathing, Chronic Opioid Use | ClinicalTrials.gov |
| Interventions | Sham Air, Supplemental Oxygen | ClinicalTrials.gov |
| First posted | 2026-11-06 | ClinicalTrials.gov |
| Last updated | 2026-11-06 | ClinicalTrials.gov |
Registered outcomes 2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Flow-Based Apnea-Hypopnea Index (AHIflow) | During each overnight intervention PSG, approximately 1 week apart | AHIflow is the number of apneas lasting at least 10 seconds plus airflow-reduction events with a greater than 30% reduction in airflow lasting at least 10 seconds, divided by total sleep time in hours. Each respiratory event is counted once. Oxygen desaturation or arousal is not required. AHIflow will be measured during each intervention PSG, and the primary treatment comparison will be the within-participant difference between the supplemental oxygen and sham air conditions. | ClinicalTrials.gov |
| Secondary | Loop Gain | During each overnight intervention PSG, approximately 1 week apart | Loop gain is a dimensionless measure of ventilatory control instability estimated from overnight polysomnography (PSG) data. Loop gain will be assessed during each intervention PSG to evaluate the effect of supplemental oxygen compared with sham air on ventilatory control. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|---|---|---|---|---|---|
| R01HL179220 | Determinants of ventilatory instability and sleep disordered breathing with chronic use of opioids | Orr, Jeremy Elliot | UNIVERSITY OF CALIFORNIA, SAN DIEGO | NATIONAL HEART LUNG AND BLOOD INSTITUTE | 2026 | NIH RePORTER |
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)