Clinical Trial Evaluating the Efficacy and Safety of Navepegritide and Lonapegsomatropin in Achondroplasia
NCT07924059, Phase 3, Not yet recruiting, Ascendis Pharma A/S
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Clinical Trial Evaluating the Efficacy and Safety of Navepegritide and Lonapegsomatropin in Achondroplasia | ClinicalTrials.gov |
| NCT number | NCT07924059 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Phase 3 | ClinicalTrials.gov |
| Enrollment | 144 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Ascendis Pharma A/S | ClinicalTrials.gov |
| Conditions | Achondroplasia | ClinicalTrials.gov |
| Interventions | Dual therapy with navepegritide and lonapegsomatropin, Dual therapy with navepegritide and placebo for lonapegsomatropin, Dual therapy with lonapegsomatropin and placebo for navepegritide | ClinicalTrials.gov |
| First posted | 2026-11-09 | ClinicalTrials.gov |
| Last updated | 2026-11-12 | ClinicalTrials.gov |
Registered outcomes 11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Annualized Growth Velocity (AGV) | 52 weeks | To evaluate the AGV, cm per year, of dual therapy with navepegritide and lonapegsomatropin compared to navepegritide alone | ClinicalTrials.gov |
| Secondary | Annualized Growth Velocity (AGV) | 52 weeks | To evaluate the AGV, cm per year, of dual therapy with navepegritide and lonapegsomatropin compared to lonapegsomatroptin alone | ClinicalTrials.gov |
| Secondary | Annualized Growth Velocity (AGV) change from baseline | 52 weeks | To evaluate the change from baseline in AGV, cm per year | ClinicalTrials.gov |
| Secondary | ACH-specific height Z-score | 52 weeks | To evaluate the change from baseline in ACH-specific height Z-score | ClinicalTrials.gov |
| Secondary | CDC-based height Z-score | 52 weeks | To evaluate the change from baseline in CDC-based height Z-score | ClinicalTrials.gov |
| Secondary | Treatment-emergent Adverse Events (AE) | Throughout trial duration 104 weeks | Number of events | ClinicalTrials.gov |
| Secondary | Bone safety | Throughout trial duration 104 weeks | Qualitative assessment with radiology | ClinicalTrials.gov |
| Secondary | Arm span Z-score | 52 weeks | Change from baseline in arm span Z-score. | ClinicalTrials.gov |
| Secondary | Upper to lower body segment ratio | 52 weeks | Change from baseline in upper to lower body segment ratio. | ClinicalTrials.gov |
| Secondary | Arm span | 52 weeks | Change from baseline in arm span, cm. | ClinicalTrials.gov |
| Secondary | Interpedicular distance (IDP) | 52 weeks | Change from baseline in IDP (L1-L4 average), mm | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)