AI-ECHO Hemodynamic Phenotyping in Septic Shock
NCT07924501, Not yet recruiting, Second Affiliated Hospital of Guangzhou Medical University
Trial 9
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | AI-ECHO Hemodynamic Phenotyping in Septic Shock | ClinicalTrials.gov |
| NCT number | NCT07924501 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Enrollment | 240 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Second Affiliated Hospital of Guangzhou Medical University | ClinicalTrials.gov |
| Conditions | Sepsis, Septic Shock, Septic Cardiomyopathy | ClinicalTrials.gov |
| Interventions | Point-of-care echocardiography | ClinicalTrials.gov |
| First posted | 2026-11-09 | ClinicalTrials.gov |
| Last updated | 2026-11-09 | ClinicalTrials.gov |
Registered outcomes 6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Echocardiography-Derived Hemodynamic Phenotypes in Adults With Septic Shock | Within 7 days after enrollment | Identification and characterization of distinct hemodynamic phenotypes in adults with septic shock using unsupervised analysis of prespecified multidimensional echocardiographic parameters. The parameters may include measures of left ventricular systolic and diastolic function, right ventricular function, cardiac output or flow, and inferior vena cava dynamics, depending on data availability and image quality. The number and characteristics of the identified phenotypes will be determined using prespecified model selection and evaluation procedures. | ClinicalTrials.gov |
| Secondary | Longitudinal Changes and Dynamic Evolution of Hemodynamic Status | Day 1, Day 3, and Day 7 after enrollment. | Serial changes in echocardiographic parameters and transitions among hemodynamic phenotypes will be evaluated during follow-up. | ClinicalTrials.gov |
| Secondary | Associations Between Hemodynamic Phenotypes and Clinical Severity and Outcomes | Within 7 days after enrollment for severity measures; up to 28 days or during the index hospitalization for clinical outcomes. | Associations of hemodynamic phenotypes with SOFA score, blood lactate, 28-day all-cause mortality, vasopressor duration, and ICU and hospital length of stay will be evaluated. | ClinicalTrials.gov |
| Secondary | Agreement Between AI-Derived and Blinded Expert Echocardiographic Measurements | Day 1, Day 3, and Day 7 after enrollment. | Agreement for prespecified echocardiographic parameters will be evaluated using intraclass correlation coefficients and Bland-Altman analyses. | ClinicalTrials.gov |
| Secondary | Associations Between Molecular Profiles and Hemodynamic Phenotypes | Day 1, Day 3, and Day 7 after enrollment. | Exploratory associations of targeted proteomic and metabolomic profiles with hemodynamic phenotypes will be evaluated. | ClinicalTrials.gov |
| Secondary | Exploratory Early-Warning Model for 28-Day All-Cause Mortality | Predictors within 7 days; mortality through 28 days after enrollment. | An exploratory model will be developed and internally validated using clinical and echocardiographic data. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)