Bilateral PENG Block for Total Vaginal Hysterectomy
NCT07925411, Early phase 1, Not yet recruiting, University of Illinois Chicago
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Bilateral PENG Block for Total Vaginal Hysterectomy | ClinicalTrials.gov |
| NCT number | NCT07925411 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Early phase 1 | ClinicalTrials.gov |
| Enrollment | 30 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | University of Illinois Chicago | ClinicalTrials.gov |
| Conditions | Pericapsular Nerve Group Block (PENG Block), Total Vaginal Hysterectomy | ClinicalTrials.gov |
| Interventions | PENG Block | ClinicalTrials.gov |
| First posted | 2026-11-09 | ClinicalTrials.gov |
| Last updated | 2026-11-09 | ClinicalTrials.gov |
Registered outcomes 12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Postoperative pain intensity during the PACU stay | 30 minutes after PACU arrival, 60 minutes after PACU arrival, and at PACU discharge | Assessed using the Numeric Rating Scale (NRS, 0-10) at PACU arrival (once awake and able to provide a reliable assessment). | ClinicalTrials.gov |
| Secondary | Proportion of participants requiring rescue opioid analgesia during the PACU stay | 30 minutes after PACU arrival, 60 minutes after PACU arrival, and at PACU discharge | ClinicalTrials.gov | |
| Secondary | Location of postoperative pain | 30 minutes after PACU arrival, 60 minutes after PACU arrival, and at PACU discharge | Self-reported by the participant at each PACU assessment and categorized as deep pelvic/vaginal, perineal/introital, suprapubic, groin/hip, medial thigh, or lower back pain | ClinicalTrials.gov |
| Secondary | Cutaneous sensory block, at each PACU pain-assessment timepoint | 30 minutes after PACU arrival, 60 minutes after PACU arrival, and at PACU discharge | assessed bilaterally in the femoral, saphenous, obturator, lateral femoral cutaneous, genitofemoral (femoral branch), and ilioinguinal/iliohypogastric territories using a 3-point scale | ClinicalTrials.gov |
| Secondary | Correspondence between the anatomical territories in which sensory block is demonstrated and the anatomical location of reported postoperative pain | 30 minutes after PACU arrival, 60 minutes after PACU arrival, and at PACU discharge | ClinicalTrials.gov | |
| Secondary | Incidence of postoperative nausea and vomiting during the PACU stay | Any time during PACU stay | ClinicalTrials.gov | |
| Secondary | Duration of PACU stay | PACU Stay | ClinicalTrials.gov | |
| Other | Lower-extremity motor weakness following bilateral PENG block, a | 30 minutes after PACU arrival, 60 minutes after PACU arrival, and at PACU discharge | Assessed bilaterally by knee extension (quadriceps, femoral nerve) and hip adduction (adductors, obturator nerve) and graded using the Medical Research Council (MRC) 0-5 scale, referenced to the participant's own preoperative baseline examination | ClinicalTrials.gov |
| Other | Persistence of sensory or motor block at PACU discharge | PACU discharge | Defined as any territory scored as reduced or absent, or any MRC grade below the participant's preoperative baseline, at the final PACU assessment | ClinicalTrials.gov |
| Other | Falls or near-falls | The postoperative observation period in PACU | ClinicalTrials.gov | |
| Other | Signs or symptoms of local anesthetic systemic toxicity | Starting from the block time until 30 min after the block | Cardiovascular System Symptoms * Early or Moderate Signs: * Blood pressure changes (initial hypertension or rapid tachycardia, progressing to low blood pressure/hypotension) * Slow heart rate (bradycardia) or heart rhythm irregularities (arrhythmias) * Conduction delays and heart blocks * Severe / Life-Threatening Signs: * Ventricular tachycardia or ventricular fibrillation * Cardiac arrest, asystole, or pulseless electrical activity (PEA | ClinicalTrials.gov |
| Other | New lower-extremity sensory or neurological symptoms following the block | 30 minutes after PACU arrival, 60 minutes after PACU arrival, and at PACU discharge | Weakness in lower-extremity and numbness | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 10
The papers the trial lists on ClinicalTrials.gov.
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)