Enhancing the Effect of Stellate Ganglion Block in the Treatment of Posttraumatic Stress Disorder: A Double-blind Randomized Controlled Trial of Bupivacaine vs Bupivacaine + Ketamine
NCT07927036, Phase 2, Not yet recruiting, The Royal's Institute of Mental Health Research
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Enhancing the Effect of Stellate Ganglion Block in the Treatment of Posttraumatic Stress Disorder: A Double-blind Randomized Controlled Trial of Bupivacaine vs Bupivacaine + Ketamine | ClinicalTrials.gov |
| NCT number | NCT07927036 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Phase 2 | ClinicalTrials.gov |
| Enrollment | 126 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | The Royal's Institute of Mental Health Research | ClinicalTrials.gov |
| Conditions | Posttraumatic Stress Disorder (PTSD) | ClinicalTrials.gov |
| Interventions | SGB Bupivacaine, SGB Bupivacaine + Ketamine | ClinicalTrials.gov |
| First posted | 2026-11-09 | ClinicalTrials.gov |
| Last updated | 2026-11-09 | ClinicalTrials.gov |
Registered outcomes 6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change of the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) total symptom severity score | From baseline to +4 weeks | The mean difference in the change of the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) total symptom severity score, specifically evaluated by comparing the Bupivacaine + Ketamine group to the Bupivacaine alone group. | ClinicalTrials.gov |
| Primary | Change of the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) total symptom severity score | From baseline to +4 weeks | The mean difference in the change of the CAPS-5 total symptom severity score , specifically evaluated by comparing the Bupivacaine + Ketamine group to the Control group. | ClinicalTrials.gov |
| Secondary | The mean change in PTSD Check List-5 (PCL-5) scores | From baseline to +4 weeks | The mean change in PCL-5 scores between the Bupivacaine + Ketamine group and the Bupivacaine alone group. | ClinicalTrials.gov |
| Secondary | The mean change in PCL-5 scores | From baseline to +4 weeks | The mean change in PCL-5 scores between the Bupivacaine + Ketamine group versus the Control group. | ClinicalTrials.gov |
| Secondary | Proportion of patients achieving reliable change (at least 14-point reduction) in the total score on Outcome Questionnaire 45 (OQ45) | from baseline to +4, +8 and +12 weeks. | Proportion of patients achieving reliable change (at least 14-point reduction) in the total score on OQ45.2 reflecting improvement in symptom burden and functioning | ClinicalTrials.gov |
| Secondary | Changes in participant's symptomatology and overall functioning from the perspective of the participant's family and support network measured by the FAST-Q | From baseline to +4 and +12 weeks | Changes in participant's symptomatology and overall functioning from the perspective of the participant's family and support network measured by the FAST-Q | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)