Effect of Lutein, Zeaxanthin, and Meso-Zeaxanthin Supplementation on Macular Sensitivity in Patients With High Myopia
NCT07927712, Phase 2, Completed, Asociación para Evitar la Ceguera en México
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Effect of Lutein, Zeaxanthin, and Meso-Zeaxanthin Supplementation on Macular Sensitivity in Patients With High Myopia | ClinicalTrials.gov |
| NCT number | NCT07927712 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Phase 2 | ClinicalTrials.gov |
| Enrollment | 70 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Asociación para Evitar la Ceguera en México | ClinicalTrials.gov |
| Conditions | High Myopia | ClinicalTrials.gov |
| Interventions | Lutein + meso-zeaxanthin + zeaxanthin (LMZ) | ClinicalTrials.gov |
| First posted | 2026-11-10 | ClinicalTrials.gov |
| Last updated | 2026-11-10 | ClinicalTrials.gov |
Registered outcomes 3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in contrast sensitivity function (LogCS) at 6 months | Baseline and 6 months (with an additional assessment at 3 months). | Contrast sensitivity was assessed using the Rabin Contrast Sensitivity Test with an adaptive algorithm at a spatial frequency of 6 cycles per degree (CPD). Results were expressed in logarithmic contrast sensitivity units (LogCS). | ClinicalTrials.gov |
| Secondary | Change in systemic skin carotenoid levels | Baseline, 3 months, and 6 months. | Skin carotenoid levels were measured using the Lifemeter system based on pressure-mediated reflectance spectroscopy. Three measurements were obtained per participant, and the average measurement value was used for analysis. | ClinicalTrials.gov |
| Other | Change in macular integrity index | Baseline, 3 months, and 6 months. | The macular integrity index was calculated by comparing each participant's retinal sensitivity map with an age-adjusted normative database. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 38
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 3372162 | BACKGROUND | PubMed |
| 6724836 | BACKGROUND | PubMed |
| 6724837 | BACKGROUND | PubMed |
| 9176055 | BACKGROUND | PubMed |
| 10369597 | BACKGROUND | PubMed |
| 10509640 | BACKGROUND | PubMed |
| 11361022 | BACKGROUND | PubMed |
| 12062535 | BACKGROUND | PubMed |
| 13035466 | BACKGROUND | PubMed |
| 17498306 | BACKGROUND | PubMed |
| 18926795 | BACKGROUND | PubMed |
| 20373901 | BACKGROUND | PubMed |
| 20876139 | BACKGROUND | PubMed |
| 21149782 | BACKGROUND | PubMed |
| 22652506 | BACKGROUND | PubMed |
| 22699751 | BACKGROUND | PubMed |
| 23224230 | BACKGROUND | PubMed |
| 23360692 | BACKGROUND | PubMed |
| 23385792 | BACKGROUND | PubMed |
| 24113300 | BACKGROUND | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 1
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Contrast Sensitivity Test | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)