A Pilot Randomized Controlled Trial of Suzetrigine as an Adjunct to Multimodal Analgesia Following Total Knee Arthroplasty
NCT07928011, Phase 4, Not yet recruiting, University of California, Irvine
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | A Pilot Randomized Controlled Trial of Suzetrigine as an Adjunct to Multimodal Analgesia Following Total Knee Arthroplasty | ClinicalTrials.gov |
| NCT number | NCT07928011 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Phase 4 | ClinicalTrials.gov |
| Enrollment | 40 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | University of California, Irvine | ClinicalTrials.gov |
| Conditions | Total Knee Arthroplasty | ClinicalTrials.gov |
| Interventions | Suzetrigine | ClinicalTrials.gov |
| First posted | 2026-11-10 | ClinicalTrials.gov |
| Last updated | 2026-11-10 | ClinicalTrials.gov |
Registered outcomes 12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Participant enrollment | At enrollment | Enrollment rates | ClinicalTrials.gov |
| Primary | Protocol adherence | Within 14 days | Protocol adherence rates | ClinicalTrials.gov |
| Primary | Data collection | At 14 days | Completeness of data collection | ClinicalTrials.gov |
| Secondary | Primary Clinical Outcome: Opioid consumption | Within 14 days | Total cumulative opioid consumption in milligrams morphine equivalents (MME) within the study period | ClinicalTrials.gov |
| Other | Pain | At 14 days | Numeric Pain Rating Scale (NPRS): Zero is equivalent to no pain and 10 indicates the worst possible pain. | ClinicalTrials.gov |
| Other | First day of walking unassisted | Within 14 days | ClinicalTrials.gov | |
| Other | Barthel Index for Activities of Daily Living (ADL) | At 14 days | Cumulative score ranges from 0 to 100, where 0 indicates complete dependence and 100 signifies total independence | ClinicalTrials.gov |
| Other | Knee injury and Osteoarthritis Outcome Score (KOOS) | At 14 days | 0 represents extreme knee problems, and 100 represents no knee problems | ClinicalTrials.gov |
| Other | Knee range of motion | At 14 days | Clinical assessment | ClinicalTrials.gov |
| Other | Time to opioid cessation | Within 14 days | ClinicalTrials.gov | |
| Other | Opioid prescription renewal | Within 14 days | ClinicalTrials.gov | |
| Other | Incidence of opioid-related adverse events | Within 14 days | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)