Molecular and Microbiome Changes During Tirzepatide Treatment and Resistance Training in Obesity
NCT07931196, Not yet recruiting, Technical University of Munich
Trial 9
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Molecular and Microbiome Changes During Tirzepatide Treatment and Resistance Training in Obesity | ClinicalTrials.gov |
| NCT number | NCT07931196 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Enrollment | 150 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Technical University of Munich | ClinicalTrials.gov |
| Conditions | Obesity (BMI Equal to or >30) | ClinicalTrials.gov |
| Interventions | Structured resistance training, Tirzepatide | ClinicalTrials.gov |
| First posted | 2026-11-12 | ClinicalTrials.gov |
| Last updated | 2026-11-12 | ClinicalTrials.gov |
Registered outcomes 8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in circulating protein biomarker profile (plasma/serum) | Baseline (Week 0) and end of treatment (Week 24) | Circulating proteins related to inflammation, metabolism and cardiovascular health measured by high-throughput proteomics (e.g., Olink®). | ClinicalTrials.gov |
| Primary | Change in frequencies of circulating lymphocyte subsets | Baseline (Week 0) and end of treatment (Week 24) | Frequencies of circulating lymphocyte subsets, including subsets defined by markers of activation, senescence and exhaustion, measured by multiparameter flow cytometry and expressed as percentage of the respective parent population. | ClinicalTrials.gov |
| Primary | Change in gut microbiome composition and diversity (stool) | Baseline (Week 0), Week 4 and end of treatment (Week 24) | Microbial composition and diversity determined by 16S rRNA sequencing and shotgun metagenomics. | ClinicalTrials.gov |
| Primary | Change in oral microbiome composition and diversity (tongue swab) | Baseline (Week 0), Week 4 and end of treatment (Week 24) | Microbial composition and diversity determined by 16S rRNA sequencing and shotgun metagenomics. | ClinicalTrials.gov |
| Primary | Change in nasal microbiome composition and diversity (nasal swab) | Baseline (Week 0), Week 4 and end of treatment (Week 24) | Microbial composition and diversity determined by 16S rRNA sequencing and shotgun metagenomics. | ClinicalTrials.gov |
| Secondary | Change in functional immune responses | Baseline (Week 0) and end of treatment (Week 24) | T-cell receptor-mediated activation and inflammasome assays, including assays using participant serum. | ClinicalTrials.gov |
| Secondary | Change in immune cell transcriptome | Baseline (Week 0) and end of treatment (Week 24) | Transcriptomic analyses of isolated immune cells, including single-cell RNA sequencing | ClinicalTrials.gov |
| Secondary | Change in microbial metabolites | Baseline (Week 0), Week 4 and end of treatment (Week 24) | Short-chain fatty acids and volatile organic compounds | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.3.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 4a570df2e7274cee2d4fa2959402fab41880e2cd412e4b590390035fbea69391 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
Release trials-2026-11-12-0.3.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.