Effects of Anesthesia on Maternal and Fetal Oxidative Stress During Cesarean Delivery
NCT07931339, Phase 4, Completed, University of Banja Luka
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Effects of Anesthesia on Maternal and Fetal Oxidative Stress During Cesarean Delivery | ClinicalTrials.gov |
| NCT number | NCT07931339 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Phase 4 | ClinicalTrials.gov |
| Enrollment | 90 participants, actual | ClinicalTrials.gov |
| Lead sponsor | University of Banja Luka | ClinicalTrials.gov |
| Conditions | Oxidative Stress, Cesarean Section | ClinicalTrials.gov |
| Interventions | Spinal Anesthesia, Propofol, Thiopental, Sevoflurane | ClinicalTrials.gov |
| First posted | 2026-11-12 | ClinicalTrials.gov |
| Last updated | 2026-11-12 | ClinicalTrials.gov |
Registered outcomes 38
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Maternal Plasma TBARS Concentration | Before anesthesia, during cesarean delivery, and 2 hours postoperatively. | Thiobarbituric acid-reactive substances (TBARS), an indicator of lipid peroxidation, measured in maternal plasma. Concentrations were compared across the three anesthesia groups and assessed at three perioperative time points. Values are expressed in mmol/L. | ClinicalTrials.gov |
| Primary | Umbilical Cord Venous Plasma TBARS Concentration | At delivery (umbilical cord venous blood sampling). | Thiobarbituric acid-reactive substances (TBARS), an indicator of lipid peroxidation, measured in umbilical cord venous plasma. Concentrations were compared across the three anesthesia groups. Values are expressed in mmol/L. | ClinicalTrials.gov |
| Primary | Placental Tissue TBARS Concentration | At delivery, immediately following placental removal. | Thiobarbituric acid-reactive substances (TBARS), an indicator of lipid peroxidation, measured in placental tissue homogenates. Concentrations were compared across the three anesthesia groups. Values are expressed in µmol/g of tissue. | ClinicalTrials.gov |
| Primary | Maternal Plasma Hydrogen Peroxide (H2O2) Concentration | Before anesthesia, after delivery and placental removal, and 2 hours postoperatively. | Hydrogen peroxide (H2O2), a marker of oxidative stress, measured in maternal plasma. Concentrations were compared across the three anesthesia groups at three perioperative time points. Values are expressed in nmol/mL. | ClinicalTrials.gov |
| Primary | Umbilical Cord Venous Plasma Hydrogen Peroxide (H2O2) Concentration | At delivery (umbilical cord venous blood sampling). | Hydrogen peroxide (H2O2), a marker of oxidative stress, measured in umbilical cord venous plasma. Concentrations were compared across the three anesthesia groups. Values are expressed in nmol/mL. | ClinicalTrials.gov |
| Primary | Maternal Plasma Superoxide Anion (O2-) Concentration | Before anesthesia, after delivery and placental removal, and 2 hours postoperatively. | Superoxide anion (O2-), a reactive oxygen species and marker of oxidative stress, measured in maternal plasma. Concentrations were compared across the three anesthesia groups at three perioperative time points. Values are expressed in nmol/mL. | ClinicalTrials.gov |
| Primary | Umbilical Cord Venous Plasma Superoxide Anion (O2-) Concentration | At delivery (umbilical cord venous blood sampling). | Superoxide anion (O2-), a reactive oxygen species and marker of oxidative stress, measured in umbilical cord venous plasma. Concentrations were compared across the three anesthesia groups. Values are expressed in nmol/mL. | ClinicalTrials.gov |
| Primary | Maternal Plasma Nitrite (NO2-) Concentration | Before anesthesia, after delivery and placental removal, and 2 hours postoperatively. | Nitrite (NO2-), an indicator of nitric oxide metabolism, measured in maternal plasma. Concentrations were compared across the three anesthesia groups at three perioperative time points. Values are expressed in nmol/mL. | ClinicalTrials.gov |
| Primary | Umbilical Cord Venous Plasma Nitrite (NO2-) Concentration | At delivery (umbilical cord venous blood sampling). | Nitrite (NO2-), an indicator of nitric oxide metabolism, measured in umbilical cord venous plasma. Concentrations were compared across the three anesthesia groups. Values are expressed in nmol/mL. | ClinicalTrials.gov |
| Primary | Maternal Erythrocyte Superoxide Dismutase (SOD) Activity | Before anesthesia, after delivery and placental removal, and 2 hours postoperatively. | Superoxide dismutase (SOD) activity, an indicator of enzymatic antioxidant defense, measured in maternal erythrocyte lysates. Activity was compared across the three anesthesia groups at three perioperative time points. Values are expressed in U/g Hgb × 10³. | ClinicalTrials.gov |
| Primary | Umbilical Cord Venous Erythrocyte Superoxide Dismutase (SOD) Activity | At delivery (umbilical cord venous blood sampling). | Superoxide dismutase (SOD) activity, an indicator of enzymatic antioxidant defense, measured in erythrocyte lysates from umbilical cord venous blood. Activity was compared across the three anesthesia groups. Values are expressed in U/g Hgb × 10³. | ClinicalTrials.gov |
| Primary | Placental Tissue Superoxide Dismutase (SOD) Activity | At delivery, following placental removal. | Superoxide dismutase (SOD) activity, an indicator of enzymatic antioxidant defense, measured in placental tissue homogenates. Activity was compared across the three anesthesia groups. Values are expressed in U/g of tissue. | ClinicalTrials.gov |
| Primary | Maternal Erythrocyte Reduced Glutathione (GSH) Concentration | Before anesthesia, after delivery and placental removal, and 2 hours postoperatively. | Reduced glutathione (GSH), a non-enzymatic antioxidant involved in cellular defense against oxidative stress, measured in maternal erythrocyte lysates. Concentrations were compared across the three anesthesia groups at three perioperative time points. Values are expressed in nmol/mL RBC. | ClinicalTrials.gov |
| Primary | Umbilical Cord Venous Erythrocyte Reduced Glutathione (GSH) Concentration | At delivery (umbilical cord venous blood sampling). | Reduced glutathione (GSH), a non-enzymatic antioxidant involved in cellular defense against oxidative stress, measured in erythrocyte lysates from umbilical cord venous blood. Concentrations were compared across the three anesthesia groups. Values are expressed in nmol/mL RBC. | ClinicalTrials.gov |
| Primary | Placental Tissue Reduced Glutathione (GSH) Concentration | At delivery, following placental removal. | Reduced glutathione (GSH), a non-enzymatic antioxidant involved in cellular defense against oxidative stress, measured in placental tissue homogenates. Concentrations were compared across the three anesthesia groups. Values are expressed in nmol/g of tissue. | ClinicalTrials.gov |
| Primary | Maternal Erythrocyte Catalase (CAT) Activity | Before anesthesia, after delivery and placental removal, and 2 hours postoperatively. | Catalase (CAT) activity, an indicator of enzymatic antioxidant defense, measured in maternal erythrocyte lysates. Activity was compared across the three anesthesia groups at three perioperative time points. Values are expressed in U/g Hgb × 10³. | ClinicalTrials.gov |
| Primary | Umbilical Cord Venous Erythrocyte Catalase (CAT) Activity | At delivery (umbilical cord venous blood sampling). | Catalase (CAT) activity, an indicator of enzymatic antioxidant defense, measured in erythrocyte lysates from umbilical cord venous blood. Activity was compared across the three anesthesia groups. Values are expressed in U/g Hgb × 10³. | ClinicalTrials.gov |
| Primary | Placental Tissue Catalase (CAT) Activity | At delivery, following placental removal. | Catalase (CAT) activity, an indicator of enzymatic antioxidant defense, measured in placental tissue homogenates. Activity was compared across the three anesthesia groups. Values are expressed in U/g of tissue. | ClinicalTrials.gov |
| Secondary | Umbilical Cord Blood pH | At delivery (umbilical cord blood sampling). | Umbilical cord blood pH measured by blood gas analysis immediately after delivery to assess neonatal acid-base status. Values were compared across the three anesthesia groups. pH is dimensionless. | ClinicalTrials.gov |
| Secondary | Umbilical Cord Blood Partial Pressure of Oxygen (pO₂) | At delivery (umbilical cord blood sampling). | Partial pressure of oxygen (pO₂) measured in umbilical cord blood by blood gas analysis to assess neonatal oxygenation at birth. Values were compared across the three anesthesia groups. Results are expressed in mmHg. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 38984000 | RESULT | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)