Laser-Assisted Disinfection With and Without Photobiomodulation in Regenerative Endodontic Procedures for Necrotic Mature Teeth
NCT07931833, Not applicable, Not yet recruiting, Future University in Egypt
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Laser-Assisted Disinfection With and Without Photobiomodulation in Regenerative Endodontic Procedures for Necrotic Mature Teeth | ClinicalTrials.gov |
| NCT number | NCT07931833 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 81 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Future University in Egypt | ClinicalTrials.gov |
| Conditions | Mature Teeth, Endodontic Regeneration | ClinicalTrials.gov |
| Interventions | regenerative endodontic procedure (REP), 810 nm diode laser-assisted canal disinfection, Photobiomodulation (810 nm diode laser) | ClinicalTrials.gov |
| First posted | 2026-11-12 | ClinicalTrials.gov |
| Last updated | 2026-11-12 | ClinicalTrials.gov |
Registered outcomes 4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in periapical lesion volume (mm3) measured on CBCT | baseline and 12 month | Periapical lesion volume in cubic millimeters measured on cone-beam computed tomography (CBCT) scans (field of view 50 x 50 mm, isometric voxel size 0.125 mm) by a blinded outcome assessor. Change from baseline to 12 months is compared among the three groups. | ClinicalTrials.gov |
| Secondary | Postoperative pain intensity (Numeric Rating Scale) | Preoperative (baseline), 6 hours, 12 hours, 24 hours, 48 hours, and 72 hours | Patient-reported pain on the Numeric Rating Scale from 0 (no pain) to 10 (worst pain imaginable), collected by telephone by a blinded study coordinator. | ClinicalTrials.gov |
| Secondary | Postoperative analgesic intake | 6 hours, 12 hours, 24 hours, 48 hours, and 72 hours | Whether any analgesic was taken since the previous assessment, with the number of doses and dose per intake, recorded at each telephone contact. | ClinicalTrials.gov |
| Secondary | Resolution of clinical signs and symptoms | Preoperative (baseline), second visit, 3 months, 6 months, and 12 months | Presence or absence of tenderness to percussion, tenderness to palpation, swelling, and sinus tract, and need for additional intervention, assessed by clinical examination by a blinded examiner. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)