Evaluation of Hyaluronic Acid Gel and Concentrated Growth Factor in Periodontal Therapy
NCT07932912, Not applicable, Completed, Amina Fouad Farag
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Evaluation of Hyaluronic Acid Gel and Concentrated Growth Factor in Periodontal Therapy | ClinicalTrials.gov |
| NCT number | NCT07932912 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 66 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Amina Fouad Farag | ClinicalTrials.gov |
| Conditions | Periodontitis | ClinicalTrials.gov |
| Interventions | Minimally invasive non-surgical therapy (MINST), 0.8% High-Molecular-Weight Hyaluronic Acid Gel, Concentrated Growth Factor (CGF), autologous | ClinicalTrials.gov |
| First posted | 2026-11-12 | ClinicalTrials.gov |
| Last updated | 2026-11-12 | ClinicalTrials.gov |
Registered outcomes 6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in Clinical Attachment Level (CAL) | Baseline, 1 month, 3 months and 6 months after treatment | Distance in millimetres from the cemento-enamel junction to the base of the pocket, measured at the experimental site (the deepest interproximal pocket) with a UNC-15 probe by a calibrated examiner. CAL gain = baseline CAL minus CAL at each follow-up. The 6-month CAL gain is the main end-point; the 1- and 3-month values describe the course of attachment gain. | ClinicalTrials.gov |
| Secondary | Change in Probing Depth (PD) | Baseline, 1, 3 and 6 months | Distance in millimetres from the gingival margin to the base of the pocket at the experimental site, measured with a UNC-15 probe. | ClinicalTrials.gov |
| Secondary | Bleeding on Probing (BoP) | Baseline, 1, 3 and 6 months | Presence or absence of bleeding within 30 seconds after gentle probing of the experimental site, reported as the number and percentage of patients with BoP. | ClinicalTrials.gov |
| Secondary | Gingival Index (GI) | Baseline, 1, 3 and 6 months | Löe \& Silness index scored 0-3 (0 = normal gingiva; 3 = severe inflammation with spontaneous bleeding) at the experimental tooth. | ClinicalTrials.gov |
| Secondary | Plaque Index (PI) | Baseline, 1, 3 and 6 months | Silness \& Löe index scored 0-3 (0 = no plaque; 3 = abundant soft deposits) at the experimental tooth. | ClinicalTrials.gov |
| Secondary | Gingival Crevicular Fluid VEGF Level | Baseline, 1, 3 and 6 months | Vascular endothelial growth factor in GCF collected with a sterile #40 paper point placed for 30 seconds at the experimental site, measured by human VEGF sandwich ELISA (pg/mL). | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)