Predicting Transitions From Depression to Wellbeing Through a Network-based Operationalization of Plasticity
NCT07933276, Not yet recruiting, IRCCS San Raffaele
Trial 9
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Predicting Transitions From Depression to Wellbeing Through a Network-based Operationalization of Plasticity | ClinicalTrials.gov |
| NCT number | NCT07933276 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Enrollment | 200 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | IRCCS San Raffaele | ClinicalTrials.gov |
| Conditions | Major Depressive Disorder (MDD) | ClinicalTrials.gov |
| Interventions | Clinical and cognitive assessments, Multimodal MRI, Blood sampling for multi-omic analyses | ClinicalTrials.gov |
| First posted | 2026-11-12 | ClinicalTrials.gov |
| Last updated | 2026-11-12 | ClinicalTrials.gov |
Registered outcomes 4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in Hamilton Depression Rating Scale (HDRS-17) total score from baseline to week 4 | Baseline to four-week follow-up | Depressive symptom severity is measured with the 17-item Hamilton Depression Rating Scale (HDRS-17), total score range 0 to 52, where higher scores indicate more severe depression (worse outcome). The outcome is the change in total score from baseline to week 4. Baseline whole-brain functional connectivity strength, derived from resting-state fMRI, is the predictor. | ClinicalTrials.gov |
| Secondary | Change in Hamilton Depression Rating Scale (HDRS-17) total score from baseline to week 4, in relation to multi-omics-derived plasticity profiles | Baseline to four-week follow-up | Depressive symptom severity is measured with the 17-item Hamilton Depression Rating Scale (HDRS-17), with a total score range of 0 to 52, where higher scores indicate more severe depression (worse outcome). The outcome is the change in total score from baseline to week 4. Multi-omics-derived plasticity profiles (genomic, transcriptomic and metabolomic data from peripheral blood collected at baseline) are the predictors. | ClinicalTrials.gov |
| Secondary | Change in Beck Depression Inventory-13 (BDI-13) total score from baseline to week 4, in relation to multi-omics-derived plasticity profiles | Baseline to four-week follow-up | Depressive symptoms are measured with the Beck Depression Inventory-13 (BDI-13), a 13-item self-report questionnaire with a total score range of 0 to 39, where higher scores indicate more severe depression (worse outcome). The outcome is the change in total score from baseline to week 4. Multi-omics-derived plasticity profiles (genomic, transcriptomic and metabolomic data from peripheral blood collected at baseline) are the predictors. | ClinicalTrials.gov |
| Other | Integrated individualized plasticity score | Baseline to four-week follow-up | Individualized plasticity score integrating symptom-based, neuroimaging-based and multi-omics-based measures, and its association with change in the total scores of the 17-item Hamilton Depression Rating Scale (HDRS-17) and the 13-item Beck Depression Inventory (BDI-13), and with contextual factors at baseline: quality of life (World Health Organization Quality of Life-BREF, WHOQOL-BREF), psychosocial stress (Schedule of Recent Experiences, SRE, and Perceived Stress Scale, PSS) and socioeconomic status. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)