Tailored Education for Aging and Cognitive Health: A Health Behavior Change Intervention for Midlife Adults at Risk for Alzheimer's Disease and Related Dementias
NCT07933367, Not applicable, Not yet recruiting, Rhode Island Hospital
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Tailored Education for Aging and Cognitive Health: A Health Behavior Change Intervention for Midlife Adults at Risk for Alzheimer's Disease and Related Dementias | ClinicalTrials.gov |
| NCT number | NCT07933367 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 280 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Rhode Island Hospital | ClinicalTrials.gov |
| Conditions | ADRD, Alzheimer's Disease, Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD), Health Behavior, Healthy Aging, Vascular Health | ClinicalTrials.gov |
| Interventions | TEACH, Basic health education | ClinicalTrials.gov |
| First posted | 2026-11-12 | ClinicalTrials.gov |
| Last updated | 2026-11-12 | ClinicalTrials.gov |
Registered outcomes 18
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Multidomain behavioral composite | baseline, 2 months (end of treatment), 4 months, 12 months | This multidomain behavioral composite score is an unweighted average of five individual health behaviors: physical activity, Mediterranean diet adherence, cognitive activity, sleep quality, and alcohol use. Z-scores (or robust z-scores based on median/median absolute deviation for non-normal variables) for each continuous component score at baseline are calculated. Individual measures include 7-day average of moderate/vigorous physical activity measured via wearable (physical activity, total sleep time), Mediterranean Diet Adherence Tool total score (diet), Florida Cognitive Activities Scale (cognitive activity), and average units of alcohol consumed in the past two weeks (alcohol). | ClinicalTrials.gov |
| Primary | Metabolic Syndrome Severity Score (MetS severity) | baseline, 2 months (end of treatment), 4 months, 12 months | Race- and sex-specific weighted z-score based on confirmatory factor analysis from NHANES data (Gurka et al., 2012, 2014). MetS severity score is based on waist circumference, blood pressure, triglycerides, HDL cholesterol, and fasting plasma glucose | ClinicalTrials.gov |
| Primary | Dementia SomaSignal Test | baseline, 2 months (end of treatment), 12 months | Proteomic ADRD risk index that predicts 20-year risk of dementia from middle age | ClinicalTrials.gov |
| Secondary | Wearable measurement of moderate/vigorous physical activity minutes | baseline, 2 months (end of treatment), 4 months, 12 months | 7-day average of moderate to vigorous physical activity minutes, collected via wearable | ClinicalTrials.gov |
| Secondary | Step count | baseline, 2 months (end of treatment), 4 months, 12 months | 7-day average step count, collected via wearable | ClinicalTrials.gov |
| Secondary | Total sleep time | baseline, 2 months (end of treatment), 4 months, 12 months | 7-day average total sleep time, collected via wearable | ClinicalTrials.gov |
| Secondary | Mediterranean Diet Adherence Tool | baseline, 2 months (end of treatment), 4 months, 12 months | standardized assessment of adherence to the Mediterranean diet (self-report) | ClinicalTrials.gov |
| Secondary | Florida Cognitive Activities Scale | baseline, 2 months (end of treatment), 4 months, 12 months | standardized assessment of cognitive activities (self-report) | ClinicalTrials.gov |
| Secondary | Consensus Sleep Diary | baseline, 2 months (end of treatment), 4 months, 12 months | standardized assessment of sleep quantity and quality (self-report) | ClinicalTrials.gov |
| Secondary | International Physical Activities Scale | baseline, 2 months (end of treatment), 4 months, 12 months | standardized assessment of types and intensity of physical activity and sitting time that people do as part of their daily lives. This can be used to estimate total activity in MET-min/week and time spent sitting. | ClinicalTrials.gov |
| Secondary | Perceived Threat of ADRD | baseline, 2 months (end of treatment), 4 months, 12 months | perceived threat and susceptibility of Alzheimer's disease and related dementias (7-item Likert scale) | ClinicalTrials.gov |
| Secondary | Dementia Awareness Questionnaire | baseline, 2 months (end of treatment), 4 months, 12 months | standardized self-report measure of dementia knowledge, including knowledge of modifiable risk factors for ADRD | ClinicalTrials.gov |
| Secondary | Motivation to Change Behavior for Dementia Risk Reduction (MOCHAD-10) | baseline, 2 months (end of treatment), 4 months, 12 months | self-report measure of self-efficacy pertaining to behaviors for dementia risk reduction | ClinicalTrials.gov |
| Secondary | Body Weight | baseline, 2 months (end of treatment), 4 months, 12 months | body weight | ClinicalTrials.gov |
| Secondary | Waist circumference | baseline, 2 months (end of treatment), 4 months, 12 months | waist circumference (cm) | ClinicalTrials.gov |
| Secondary | Lipid panel | baseline, 2 months (end of treatment), 4 months, 12 months | Obtained via fasting blood draw. Total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides. | ClinicalTrials.gov |
| Secondary | Systolic blood pressure | baseline, 2 months (end of treatment), 4 months, 12 months | systolic blood pressure (average of 3 measurements) | ClinicalTrials.gov |
| Secondary | Hemoglobin A1C | baseline, 2 months (end of treatment), 4 months, 12 months | Glycated hemoglobin, a measure of average blood sugar over the past 2-3 months | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)