Lifestyle Strategies to Preserve Muscle and Reduce Cardiovascular Risk in Adults With Obesity Using GLP-1 Receptor Agonists
NCT07933393, Not applicable, Not yet recruiting, University of Florida
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Lifestyle Strategies to Preserve Muscle and Reduce Cardiovascular Risk in Adults With Obesity Using GLP-1 Receptor Agonists | ClinicalTrials.gov |
| NCT number | NCT07933393 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 670 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | University of Florida | ClinicalTrials.gov |
| Conditions | Obesity & Overweight | ClinicalTrials.gov |
| Interventions | GLP-1 Lifestyle Management Program, Enhanced Usual Care Health Education | ClinicalTrials.gov |
| First posted | 2026-11-12 | ClinicalTrials.gov |
| Last updated | 2026-11-12 | ClinicalTrials.gov |
Registered outcomes 8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in Appendicular Lean Tissue Mass | Baseline to 6 months | Change in appendicular lean tissue mass measured by dual-energy X-ray absorptiometry (DXA), expressed in kilograms (kg). | ClinicalTrials.gov |
| Secondary | Change in Atherosclerotic Cardiovascular Disease (ASCVD) Risk | Baseline to 6 months and 12 months | Change in estimated 10-year atherosclerotic cardiovascular disease risk calculated using the American Heart Association PREVENT risk equations. Clinical and laboratory variables are combined to generate a single estimated risk percentage (0-100%), with higher percentages indicating greater cardiovascular risk. | ClinicalTrials.gov |
| Secondary | Change in SF-36v2 Physical Component Summary Score | Baseline to 6 months and 12 months | Change in the Physical Component Summary (PCS) score of the 36-Item Short Form Health Survey, Version 2 (SF-36v2). Higher scores indicate better physical health-related quality of life. The PCS is calculated using norm-based scoring, standardized to a mean of 50 and a standard deviation of 10 in the reference population. Higher scores indicate better physical health-related quality of life. | ClinicalTrials.gov |
| Secondary | Change in SF-36v2 Mental Component Summary Score | Baseline to 6 months and 12 months | Change in the Mental Component Summary (MCS) score of the 36-Item Short Form Health Survey, Version 2 (SF-36v2). Higher scores indicate better mental health-related quality of life. The MCS is calculated using norm-based scoring, standardized to a mean of 50 and a standard deviation of 10 in the reference population. Higher scores indicate better mental health-related quality of life. | ClinicalTrials.gov |
| Secondary | Change in Total Hip Bone Mineral Density | Baseline to 6 months and 12 months | Change in total hip bone mineral density measured by dual-energy X-ray absorptiometry (DXA), expressed in grams per square centimeter (g/cm²). | ClinicalTrials.gov |
| Secondary | Change in Lumbar Spine Bone Mineral Density | Baseline to 6 months and 12 months | Change in lumbar bone mineral density measured by dual-energy X-ray absorptiometry (DXA), expressed in grams per square centimeter (g/cm²). | ClinicalTrials.gov |
| Secondary | Change in Body Weight | Baseline to 6 months and 12 months | Change in body weight measured using a calibrated scale, expressed in kilograms (kg). | ClinicalTrials.gov |
| Secondary | Change in Total Lean Mass | Baseline to 6 months and 12 months | Change in total lean mass measured by whole-body dual-energy X-ray absorptiometry (DXA), expressed in kilograms (kg). | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)