This special issue highlights peer-reviewed research presented at the 25th Annual Scientific Conference of the National Hispanic Science Network (NHSN), held under the theme “¡Sí Se Puede! The Power of Community and Innovation in Hispanic Health Research.” The selected works explore innovative approaches to addressing health disparities affecting Hispanic/Latino populations, with a strong emphasis on community-driven solutions, interdisciplinary collaboration, and translational impact. Topics include substance use, mental health, chronic disease, and the social determinants of health. The issue serves as a platform for showcasing cutting-edge research that advances understanding and promotes health equity through culturally informed, community-centered innovation.