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Cell line · CVCL_0005

NB4

Cancer cell line, Homo sapiens. Acute promyelocytic leukemia with PML-RARA. 62 papers.

4 sourcescell-lines-2026-11-14-0.1.0

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ConductScience Library. NB4. Cell lines, record CVCL_0005. Release cell-lines-2026-11-14-0.1.0, 14 Nov 2026. https://conductscience.org/library/cell-lines/CVCL_0005

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Cell line

As Cellosaurus gives it.

Name
NB4
Accession
CVCL_0005
RRID
RRID:CVCL_0005
Synonyms
NB-4, NB.4
Species
Homo sapiens (Human)
Sex
Female
Age at sampling
23Y
Category
Cancer cell line
Diseases
Acute promyelocytic leukemia with PML-RARA (NCIt C3182); Acute promyelocytic leukemia (ORDO Orphanet_520)
Derived from
Bone marrow (in situ)
Entry created
2012-04-04
Entry updated
2026-06-25

Source Cellosaurus

Problems0

Cellosaurus records no problem for this cell line.

None in this release.

Papers62

PaperJournalYearHow we knowRetractedSource
Extracellular vesicle-delivered siRNA targeting RCN1 suppresses acute myeloid leukemia through TFAM-dependent mtDNA-cGAS-STING signaling.Extracell Vesicles Circ Nucl Acids2026Its Methods give the RRID and name the linePubMed
Greatwall kinase regulates acute myeloid leukaemia cell division through a non-canonical mechanism.EMBO Rep2026Its Methods give the RRID and name the linePubMed
Novel noscapine derivative induces AML differentiation by dual-engaging DHODH and mitochondrial lipids to trigger a metabolic-epigenetic-transcriptional cascade.Acta Pharm Sin B2026Its Methods give the RRID and name the linePubMed
A structure-based modeling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia.iScience2026Its Methods give the RRID and name the linePubMed
Intracellular iron homeostasis-regulated epigenetic reprogramming contributes to -7/del(7q) leukemia.Nat Commun2026Its Methods give the RRID and name the linePubMed
Integrative multi-omics, machine learning, and experimental validation reveal that TPM1 suppresses M2 macrophage polarization and enhances chemosensitivity in acute myeloid leukemia.Cell Biol Toxicol2026Its Methods give the RRID and name the linePubMed
Sialic acid cis-ligand dynamics modulate Siglec-7 and -9 function and affect Siglec-7/9 co-blockade to potentiate natural killer cell anti-tumor activity.Oncoimmunology2026Its Methods give the RRID and name the linePubMed
RBM15B recognizes H3K79me2 to guide selective m6A-modification of mRNA and enhance oncoprotein translation in MLL-r leukemia.EMBO J2026Its Methods give the RRID and name the linePubMed
ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia.Cell Rep Med2026Its Methods give the RRID and name the linePubMed
New drug targets for acute myeloid leukemia identified through a comprehensive analysis of the plasma protein.BMC Cancer2025Its Methods give the RRID and name the linePubMed

1 to 10 of 62

See all 62 papers

Relatives15

RelationCell lineAccessionProblemSource
Derived from itEDITGENE NB4-Cas9CVCL_F5R0Cell lines
Derived from itHyCyte NB4 stable cell line for hBCL6B overexpressionCVCL_F4SQCell lines
Derived from itNB4-A1CVCL_VV77Cell lines
Derived from itNB4-AsRCVCL_U080Cell lines
Derived from itNB4-B1CVCL_VV78Cell lines
Derived from itNB4-D5CVCL_VV79Cell lines
Derived from itNB4-DR1CVCL_U085Cell lines
Derived from itNB4-LR1CVCL_8811Cell lines
Derived from itNB4-S1CVCL_U086Cell lines
Derived from itNB4.007/6CVCL_U083Cell lines

1 to 10 of 15

See all 15 relatives

Cell banks5

Cell bankCatalog numberStatusSource
CLS300299CLS
DSMZACC-207DSMZ
EDITGENEEDC00350EDITGENE
NCBI_IranC515Cellosaurus
UbigeneYC-C122Ubigene

Data dates

The date of each source this release read.

Cellosaurus
2026-10-22
Cellosaurus
PubMed Central's articles
2026-11-12
PubMed Central's articles
Our copy of PubMed
2026-11-06
Our copy of PubMed

Sources 4

  • CellosaurusCC BY 4.0, with credit to Cellosaurus (SIB)
  • PubMed Central's articlesTitles shown only for CC0, CC BY and public domain articles
  • NLM's PMC Article DatasetsCourtesy of NLM, which does not endorse this database
  • PubMedNLM's terms
Each source's terms
  • CellosaurusCC BY 4.0. Cellosaurus's README: "we have chosen to apply the Creative Commons Attribution 4.0 International (CC BY 4.0) license to Cellosaurus (https://creativecommons.org/licenses/by/4.0/). This means that you are free to copy and redistribute Cellosaurus in any medium or format. You can remix, transform, and build upon Cellosaurus for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made." Copyright (c) CALIPHO group, SIB Swiss Institute of Bioinformatics. Read on 14 Nov 2026 at https://ftp.expasy.org/databases/cellosaurus/README
  • PubMed Central's articlesEach article's own license. Its words show only under CC0, CC BY or public domain
  • NLM's PMC Article DatasetsNLM's PMC Article Datasets on AWS, https://registry.opendata.aws/ncbi-pmc. Its terms: users "acknowledge NLM as the source of the data in a clear and conspicuous manner", do not use the PubMed Central wordmark or the PMC logo, do not "indicate or imply that NLM/NIH/HHS has endorsed" a product, and "only distribute data that are licensed for redistribution". Each article keeps its own license: https://pmc.ncbi.nlm.nih.gov/about/copyright/
  • PubMedNLM's terms

Cellosaurus, SIB Swiss Institute of Bioinformatics, https://www.cellosaurus.org, CC BY 4.0. Its problem notes are given in its own words.

For software

Read this cell line from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/cell-lines/v1/CVCL_0005

GET https://conductscience.org/api/cell-lines/v1/CVCL_0005/papers?page=2

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